Staedt J, Wassmuth F, Stoppe G, Hajak G, Rodenbeck A, Poser W, Rüther E
Department of Psychiatry, Georg August University, Göttingen, Germany.
Eur Arch Psychiatry Clin Neurosci. 1996;246(6):305-9. doi: 10.1007/BF02189023.
Previous studies have described sleep disturbance secondary to chronic opiate use and abuse. Drug-dependency insomnia is of interest because chronic sleep disturbances can promote depressive symptoms which could lead to a drug relapse. For the first time we compared the polysomnographic parameters of 10 methadone-substituted outpatients and 10 naltrexone-treated outpatients. Methadone (mu-opioid agonist) produced a marked fragmentation of the sleep architecture with frequent awakenings and a decrease in EEG arousals. In comparison with methadone and controls, the naltrexone (mu-opioid antagonist) group showed the shortest sleep latency and the longest total sleep time. These data indicate that mu-agonists and mu-antagonists have different effects on sleep. The implications, especially the involvement of opioid-dopamine interactions on sleep and movements during sleep, are discussed.
以往的研究描述了慢性阿片类药物使用和滥用继发的睡眠障碍。药物依赖性失眠备受关注，因为慢性睡眠障碍会引发抑郁症状，进而可能导致药物复吸。我们首次比较了10名接受美沙酮替代治疗的门诊患者和10名接受纳曲酮治疗的门诊患者的多导睡眠图参数。美沙酮（μ-阿片受体激动剂）导致睡眠结构明显碎片化，频繁觉醒，脑电图觉醒减少。与美沙酮组和对照组相比，纳曲酮（μ-阿片受体拮抗剂）组的睡眠潜伏期最短，总睡眠时间最长。这些数据表明，μ-激动剂和μ-拮抗剂对睡眠有不同影响。本文还讨论了其意义，特别是阿片-多巴胺相互作用对睡眠及睡眠中运动的影响。
