盐肤木虫瘿对 A375 和 SK-MEL-3 人恶性黑素瘤细胞系的选择性细胞毒性。
The Selective Cytotoxicity of Quercus Brantii Lindl. Galls on A375 and SK-MEL-3 Human Malignant Melanoma Cell Lines.
机构信息
Department of Traditional Pharmacy, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Asian Pac J Cancer Prev. 2023 Jul 1;24(7):2383-2388. doi: 10.31557/APJCP.2023.24.7.2383.
This study aimed to find out the mechanism of cytotoxic effects of galls of Quercus Brantii on A375 and SK-MEL-3 melanoma and AGO-1522 normal human fibroblast cell lines for the first time. Therefore, cell viability and cytotoxic activities were evaluated. Furthermore, ROS formation, lipid peroxidation, and release of cytochrome-c were also assessed. The results revealed that the extract of these galls at a concentration of 0.05 mg/ml significantly (P<0.001) increased cytotoxicity, ROS formation, TBARS formation, and cytochrome-c release in A375 and SK-MEL-3 melanoma cell lines compared to AGO-1522 normal human fibroblast. These results demonstrated that these galls can be considered a promising candidate which acts in synergy with anticancer agents used in the clinical treatment of human malignant melanoma.
本研究首次旨在探讨盐肤木虫瘿对 A375 和 SK-MEL-3 黑色素瘤及 AGO-1522 正常人成纤维细胞系的细胞毒性作用机制。为此，评估了细胞活力和细胞毒性作用。此外，还评估了 ROS 形成、脂质过氧化和细胞色素-c 的释放。结果表明，与 AGO-1522 正常人成纤维细胞相比，浓度为 0.05mg/ml 的这些虫瘿提取物可显著（P<0.001）增加 A375 和 SK-MEL-3 黑色素瘤细胞系的细胞毒性、ROS 形成、TBARS 形成和细胞色素-c 释放。这些结果表明，这些虫瘿可被视为一种有前途的候选物，可与用于临床治疗人类恶性黑色素瘤的抗癌药物协同作用。
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