1 型糖尿病遗传风险评分可区分易酮症糖尿病亚组。
Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes.
机构信息
Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
DHR Health, Edinburg, TX.
出版信息
Diabetes Care. 2023 Oct 1;46(10):1778-1782. doi: 10.2337/dc23-0622.
OBJECTIVE
To determine whether genetic risk for type 1 diabetes (T1D) differentiates the four Aβ subgroups of ketosis-prone diabetes (KPD), where A+ and A- define the presence or absence of islet autoantibodies and β+ and β- define the presence or absence of β-cell function.
RESEARCH DESIGN AND METHODS
We compared T1D genetic risk scores (GRS) of patients with KPD across subgroups, race/ethnicity, β-cell function, and glycemia.
RESULTS
Among 426 patients with KPD (54% Hispanic, 31% African American, 11% White), rank order of GRS was A+β- > A+β+ = A-β- > A-β+. GRS of A+β- KPD was lower than that of a T1D cohort, and GRS of A-β+ KPD was higher than that of a type 2 diabetes cohort. GRS was lowest among African American patients, with a similar distribution across KPD subgroups.
CONCLUSIONS
T1D genetic risk delineates etiologic differences among KPD subgroups. Patients with A+β- KPD have the highest and those with A-β+ KPD the lowest GRS.
目的
确定是否存在 1 型糖尿病（T1D）遗传风险，从而区分酮症倾向糖尿病（KPD）的四个 Aβ亚组，其中 A+和 A-定义是否存在胰岛自身抗体，β+和 β-定义是否存在β细胞功能。
研究设计和方法
我们比较了 KPD 患者在亚组、种族/民族、β细胞功能和血糖水平方面的 T1D 遗传风险评分（GRS）。
结果
在 426 名 KPD 患者中（54%为西班牙裔，31%为非裔美国人，11%为白人），GRS 的排序为 A+β- > A+β+ = A-β- > A-β+。A+β- KPD 的 GRS 低于 T1D 队列，A-β+ KPD 的 GRS 高于 2 型糖尿病队列。GRS 在非裔美国人患者中最低，KPD 亚组之间的分布相似。
结论
T1D 遗传风险划定了 KPD 亚组之间的病因差异。A+β- KPD 患者的 GRS 最高，而 A-β+ KPD 患者的 GRS 最低。
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