传出迷走神经的分子细胞类型作为功能单位。
Molecular cell types as functional units of the efferent vagus nerve.
机构信息
Biomedical Sciences Graduate Program, University of Virginia, Charlottesville, VA 22903, USA.
Department of Pharmacology, University of Virginia, Charlottesville, VA 22903, USA.
出版信息
Semin Cell Dev Biol. 2024 Mar 15;156:210-218. doi: 10.1016/j.semcdb.2023.07.007. Epub 2023 Jul 26.
The vagus nerve vitally connects the brain and body to coordinate digestive, cardiorespiratory, and immune functions. Its efferent neurons, which project their axons from the brainstem to the viscera, are thought to comprise "functional units" - neuron populations dedicated to the control of specific vagal reflexes or organ functions. Previous research indicates that these functional units differ from one another anatomically, neurochemically, and physiologically but have yet to define their identity in an experimentally tractable way. However, recent work with genetic technology and single-cell genomics suggests that genetically distinct subtypes of neurons may be the functional units of the efferent vagus. Here we review how these approaches are revealing the organizational principles of the efferent vagus in unprecedented detail.
迷走神经将大脑和身体至关重要地连接起来，以协调消化、心肺和免疫功能。其传出神经元（其轴突从脑干投射到内脏）被认为构成了“功能单位”——专门用于控制特定迷走反射或器官功能的神经元群体。先前的研究表明，这些功能单位在解剖学、神经化学和生理学上彼此不同，但尚未以可实验处理的方式定义其身份。然而，最近使用遗传技术和单细胞基因组学的工作表明，遗传上不同的神经元亚型可能是传出迷走神经的功能单位。在这里，我们回顾了这些方法如何以前所未有的细节揭示传出迷走神经的组织原则。
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