PermaNet Dual 是一种新的氯菊酯-氯氰菊酯混合蚊帐，在贝宁南部对拟除虫菊酯耐药的冈比亚按蚊显示出更好的效果。

PermaNet Dual, a new deltamethrin-chlorfenapyr mixture net, shows improved efficacy against pyrethroid-resistant Anopheles gambiae sensu lato in southern Benin.

机构信息

London School of Hygiene & Tropical Medicine, London, UK.

Centre de Recherche Entomologique de Cotonou, Cotonou, Benin.

出版信息

Sci Rep. 2023 Jul 28;13(1):12232. doi: 10.1038/s41598-023-39140-3.

Pyrethroid-chlorfenapyr nets have demonstrated improved entomological and epidemiological impact in trials across Africa. This is driving increased demand for this novel net class in malaria-endemic countries. PermaNet Dual is a new deltamethrin-chlorfenapyr net developed by Vestergaard Sàrl to provide more options to malaria control programmes. We performed an experimental hut trial to evaluate the efficacy of PermaNet Dual against wild, free-flying pyrethroid-resistant Anopheles gambiae sensu lato in Covè, Benin. PermaNet Dual induced superior levels of mosquito mortality compared to a pyrethroid-only net and a pyrethroid-piperonyl butoxide net both when unwashed (77% with PermaNet Dual vs. 23% with PermaNet 2.0 and 56% with PermaNet 3.0, p < 0.001) and after 20 standardised washes (75% with PermaNet Dual vs. 14% with PermaNet 2.0 and 30% with PermaNet 3.0, p < 0.001). Using a provisional non-inferiority margin defined by the World Health Organisation, PermaNet Dual was also non-inferior to a pyrethroid-chlorfenapyr net that has demonstrated improved public health value (Interceptor G2), for vector mortality (79% vs. 76%, OR = 0.878, 95% CIs 0.719-1.073) but not for blood-feeding protection (35% vs. 26%, OR = 1.424, 95% CIs 1.177-1.723). PermaNet Dual presents an additional option of this highly effective net class for improved control of malaria transmitted by pyrethroid-resistant mosquitoes.

拟除虫菊酯-氯菊酯蚊帐在非洲各地的试验中表现出更好的昆虫学和流行病学效果。这促使疟疾流行国家对这种新型蚊帐的需求增加。PermaNet Dual 是 Vestergaard Sàrl 开发的一种新型氯菊酯-氯菊酯蚊帐，旨在为疟疾控制项目提供更多选择。我们在贝宁科韦进行了一项野外小屋试验，以评估 PermaNet Dual 对野生、自由飞行的抗拟除虫菊酯按蚊的效果。与仅含拟除虫菊酯的蚊帐和含拟除虫菊酯-增效醚的蚊帐相比，PermaNet Dual 诱导的蚊虫死亡率更高，无论是在未经清洗时（PermaNet Dual 为 77%，PermaNet 2.0 为 23%，PermaNet 3.0 为 56%，p<0.001）还是在经过 20 次标准清洗后（PermaNet Dual 为 75%，PermaNet 2.0 为 14%，PermaNet 3.0 为 30%，p<0.001）。使用世界卫生组织定义的暂定非劣效性边界，PermaNet Dual 在控制由抗拟除虫菊酯蚊虫传播的疟疾方面也不劣于一种已证明具有更高公共卫生价值的拟除虫菊酯-氯菊酯蚊帐（Interceptor G2），在控制蚊虫死亡率方面（79%比 76%，比值比[OR]为 0.878，95%置信区间[CI]为 0.719-1.073），但在控制血液摄入保护方面（35%比 26%，OR 为 1.424，95%CI 为 1.177-1.723）并不占优势。PermaNet Dual 为控制由抗拟除虫菊酯蚊虫传播的疟疾提供了一种更有效的蚊帐选择。