糖尿病或糖尿病前期的存在增加了台湾人群心脏病死亡的风险：一项为期 10 年的随访研究。

The Presence of Diabetes Mellitus or Pre-diabetes Mellitus Increases Mortality from Heart Disease in a Taiwanese Population: A 10-year Follow-Up Study.

机构信息

Department of Family Medicine, Taichung Armed Forces General Hospital, No. 348, Sec. 2, Zhongshan Rd., Taiping Dist, Taichung, 41148, Taiwan.

Department of Occupational Medicine, Taichung Veterans General Hospital, Taichung, 40705, Taiwan.

出版信息

BMC Cardiovasc Disord. 2023 Jul 28;23(1):375. doi: 10.1186/s12872-023-03406-5.

DOI:10.1186/s12872-023-03406-5

PMID:37507664

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10375620/

Abstract

BACKGROUND

We evaluated hyperglycemia-associated mortality in the Taiwanese population by conducting a 10-year retrospective cohort study.

METHODS

From 2007 to 2017, all participants, regardless of their age or underlying diseases, were identified at a Health Screening Center in Taiwan. Overall, 114,534 participants were included in the analysis. They were classified into three subgroups according to glycemia and smoking status by combining survival for data analysis.

RESULTS

The mean follow-up time, age, and body mass index (BMI) were 8.14 ± 2.22 years, 40.95 ± 12.14 years, and 23.24 ± 3.65 kg/m, respectively. The cumulative death rate increased from 0.9% in the normal fasting blood glucose(FBG) subgroup to approximately 6% in the diabetes FBG subgroup. After adjusting for age, gender, BMI, high-density lipoprotein, triglycerides, waist circumference(WC), and smoking status, the hazard ratio (HR) for all-cause, cancer, and heart disease mortality in the diabetes mellitus(DM) subgroup was 1.560, 1.381, and 1.828, respectively.HR was 0.989 in all-cause, 0.940 in cancer, and 1.326 in heart disease in the pre-DM subgroup.

CONCLUSION

Being tested for pre-DM is related to a higher risk of death from heart disease in the Taiwanese population at baseline. Therefore, cardiovascular risk must be actively measured among diabetes patients every visit.

摘要

背景

我们通过进行一项为期 10 年的回顾性队列研究，评估了台湾人群中与高血糖相关的死亡率。

方法

2007 年至 2017 年，在台湾的健康筛查中心，我们确定了所有参与者，无论其年龄或基础疾病如何。共有 114534 名参与者被纳入分析。他们根据血糖和吸烟状况分为三组，通过结合生存数据进行分析。

结果

平均随访时间、年龄和体重指数（BMI）分别为 8.14±2.22 年、40.95±12.14 年和 23.24±3.65kg/m2。累积死亡率从正常空腹血糖（FBG）亚组的 0.9%上升到糖尿病 FBG 亚组的约 6%。在调整年龄、性别、BMI、高密度脂蛋白、甘油三酯、腰围（WC）和吸烟状况后，糖尿病亚组的全因、癌症和心脏病死亡率的危险比（HR）分别为 1.560、1.381 和 1.828。在预糖尿病亚组中，全因的 HR 为 0.989，癌症为 0.940，心脏病为 1.326。