Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, P. R. China.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
J Nanobiotechnology. 2023 Jul 28;21(1):244. doi: 10.1186/s12951-023-02023-w.
Neuroblastoma is one of the common extracranial tumors in children (infants to 2 years), accounting for 8 ~ 10% of all malignant tumors. Few special drugs have been used for clinical treatment currently.
In this work, herbal extract ginsenosides were used to synthesize fluorescent ginsenosides carbon nanodots via a one-step hydrothermal method. At a low cocultured concentration (50 µg·mL) of ginsenosides carbon nanodots, the inhibition rate and apoptosis rate of SH-SY5Y cells reached ~ 45.00% and ~ 59.66%. The in vivo experiments showed tumor volume and weight of mice in ginsenosides carbon nanodots group were ~ 49.81% and ~ 34.14% to mice in model group. Since ginsenosides were used as sole reactant, ginsenosides carbon nanodots showed low toxicity and good animal response.
Low-cost ginsenosides carbon nanodots as a new type of nanomedicine with good curative effect and little toxicity show application prospects for clinical treatment of neuroblastoma. It is proposed a new design for nanomedicine based on bioactive carbon nanodots, which used natural bioactive molecules as sole source.
神经母细胞瘤是儿童（婴儿至 2 岁）常见的颅外肿瘤之一，占所有恶性肿瘤的 8%至 10%。目前临床上使用的特殊药物很少。
在这项工作中，采用一步水热法，用草药提取物人参皂苷合成了荧光人参皂苷碳点。在低共培养浓度（50μg·mL）的人参皂苷碳点下，SH-SY5Y 细胞的抑制率和凋亡率达到约 45.00%和约 59.66%。体内实验表明，人参皂苷碳点组小鼠的肿瘤体积和重量分别为模型组小鼠的约 49.81%和约 34.14%。由于人参皂苷被用作唯一的反应物，人参皂苷碳点表现出低毒性和良好的动物反应。
低成本的人参皂苷碳点作为一种新型的纳米药物，具有良好的疗效和低毒性，为神经母细胞瘤的临床治疗提供了应用前景。提出了一种基于生物活性碳点的新型纳米药物设计，该设计使用天然生物活性分子作为唯一来源。
