State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin, 541004, China.
Adv Healthc Mater. 2022 Jun;11(12):e2102759. doi: 10.1002/adhm.202102759. Epub 2022 Feb 24.
Tumor microenvironment (TME)-activated cancer imaging and therapy is a key to achieving accurate diagnosis and treatment of cancer and reducing the side effects. Herein, smart near-infrared carbon dot-metal organic framework MIL-100 (Fe) assemblies are constructed to achieve TME-activated cancer imaging and chemodynamic-photothermal combined therapy. First, a near-infrared emission carbon dot (RCDs) is developed using glutathione (GSH) as the precursor. Then, the RCDs@MIL-100 self-assemblies are obtained using RCDs, FeCl , and trimesic acid solutions as raw materials. After the RCDs@MIL-100 enters the TME, a high concentration of GSH reduces Fe to Fe and drains the GSH, triggering the collapse of RCDs@MIL-100 skeleton and the release of RCDs and Fe , at which time the RCDs fluorescence is restored and in an "on" state to illuminate the tumor cells, which achieved cancer imaging. The released Fe reacts with H O in the TME to form highly reactive hydroxyl radicals (•OH) by Fenton reaction, which achieves the chemodynamic therapy of tumors. Thus, efficient synergistic chemodynamic-photothermal dual mode therapy is achieved under fluorescence imaging guidance with TME response.
肿瘤微环境（TME）激活的癌症成像和治疗是实现癌症精准诊断和治疗、降低副作用的关键。在此，构建了智能近红外碳点-金属有机骨架 MIL-100（Fe）组装体，以实现 TME 激活的癌症成像和化学动力学-光热联合治疗。首先，使用谷胱甘肽（GSH）作为前体制备近红外发射碳点（RCDs）。然后，使用 RCDs、FeCl 和均苯三甲酸溶液作为原料获得 RCDs@MIL-100 自组装体。当 RCDs@MIL-100 进入 TME 时，高浓度的 GSH 将 Fe 还原为 Fe，并耗尽 GSH，触发 RCDs@MIL-100 骨架的崩溃和 RCDs 和 Fe 的释放，此时 RCDs 荧光恢复并处于“开启”状态，照亮肿瘤细胞，从而实现癌症成像。释放的 Fe 在 TME 中与 H O 反应，通过 Fenton 反应形成高反应性羟基自由基（•OH），从而实现肿瘤的化学动力学治疗。因此，在荧光成像引导下，TME 响应下实现了高效协同的化学动力学-光热双重模式治疗。
