Sulyok Endre, Farkas Balint, Bodis Jozsef
National Laboratory on Human Reproduction, University of Pécs, 7624 Pécs, Hungary.
Faculty of Health Sciences, Doctoral School of Health Sciences, University of Pécs, 7624 Pécs, Hungary.
Antioxidants (Basel). 2023 Jun 28;12(7):1354. doi: 10.3390/antiox12071354.
Based on epidemiological observations Barker et al. put forward the hypothesis/concept that an adverse intrauterine environment (involving an insufficient nutrient supply, chronic hypoxia, stress, and toxic substances) is an important risk factor for the development of chronic diseases later in life. The fetus responds to the unfavorable environment with adaptive reactions, which ensure survival in the short run, but at the expense of initiating pathological processes leading to adult diseases. In this review, the major mechanisms (including telomere dysfunction, epigenetic modifications, and cardiovascular-renal-endocrine-metabolic reactions) will be outlined, with a particular emphasis on the role of oxidative stress in the fetal origin of adult diseases.
基于流行病学观察，巴克等人提出了这样的假说/概念：子宫内不良环境（包括营养供应不足、慢性缺氧、应激和有毒物质）是日后发生慢性疾病的重要危险因素。胎儿会通过适应性反应来应对这种不利环境，这些反应在短期内确保了生存，但却以启动导致成人疾病的病理过程为代价。在这篇综述中，将概述主要机制（包括端粒功能障碍、表观遗传修饰以及心血管-肾脏-内分泌-代谢反应），尤其强调氧化应激在成人疾病胎儿起源中的作用。
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