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利用酿酒副产物对聚乳酸进行功能化以用于生物医学应用

Use of Winemaking By-Products for the Functionalization of Polylactic Acid for Biomedical Applications.

作者信息

Verano-Naranjo Lidia, Cejudo-Bastante Cristina, Casas Lourdes, Martínez de la Ossa Enrique, Mantell Casimiro

机构信息

Chemical Engineering and Food Technology Department, Science Faculty, Wine and Agrifood Research Institute (IVAGRO), University of Cadiz, Puerto Real, 11510 Cadiz, Spain.

出版信息

Antioxidants (Basel). 2023 Jul 13;12(7):1416. doi: 10.3390/antiox12071416.

Abstract

The addition of naturally active compounds to implantable polymers is an efficient strategy against inflammation issues that might lead to rejection, while promoting controlled re-endothelialization of the tissues. This work proposes the use of winemaking by-products with high active properties of biomedical interest to obtain bioactive PLA by using supercritical technologies. First, two red grape pomace extracts, obtained by high-pressure extraction with supercritical CO and cosolvents (either ethanol or water-ethanol), have been studied. Second, two impregnation methods have been studied with both extracts, traditional supercritical CO-assisted impregnation (SSI) and a novel pressurized soaking method (PSI). The amount of extract impregnated as well as the bioactivity levels achieved-i.e., antioxidant, antimicrobial, and anti-inflammatory properties- have been determined for each extract and impregnation method at different pressure and temperature conditions. Both extracts obtained had good antioxidant, anti-inflammatory, and antibacterial capacities, especially the hydroethanolic one (0.50 ± 0.03 mg TE/g versus 0.24 ± 0.03 mg TE/g, respectively). Regarding impregnated filaments, impregnation loadings depended especially on the extract and P/T conditions, providing up to 8% (extract mass/polymer mass) of impregnation. The antioxidant capacity increased noteworthily by using the ethanolic extract by PSI, with values near 100 µg TE/g PLA.

摘要

将天然活性化合物添加到可植入聚合物中是一种有效的策略,可解决可能导致排斥反应的炎症问题,同时促进组织的可控再内皮化。这项工作提出利用具有高生物医学活性的酿酒副产品,通过超临界技术获得生物活性聚乳酸。首先,研究了两种通过超临界二氧化碳和共溶剂(乙醇或水 - 乙醇)高压萃取得到的红葡萄皮渣提取物。其次,研究了两种用这两种提取物的浸渍方法,传统的超临界二氧化碳辅助浸渍(SSI)和一种新型的加压浸泡方法(PSI)。在不同的压力和温度条件下,针对每种提取物和浸渍方法,测定了浸渍的提取物量以及所达到的生物活性水平,即抗氧化、抗菌和抗炎特性。得到的两种提取物都具有良好的抗氧化、抗炎和抗菌能力,尤其是水乙醇提取物(分别为0.50±0.03毫克TE/克和0.24±0.03毫克TE/克)。关于浸渍的长丝,浸渍量尤其取决于提取物和压力/温度条件,提供高达8%(提取物质量/聚合物质量)的浸渍量。通过PSI使用乙醇提取物时,抗氧化能力显著提高,聚乳酸的值接近100微克TE/克。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7171/10376806/0625235a5044/antioxidants-12-01416-g001.jpg

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