Keeler R F, Johnson A E, Stuart L D, Evans J O
Vet Hum Toxicol. 1986 Aug;28(4):309-15.
Galega officinalis L (goatsrue), a plant introduced from Europe and found in abundance in northern Utah, was tested for toxicity in ewes (Ovis aries). Clinical signs of poisoning induced by doses as small as 0.8 g of dried plant/kg body weight/day included dyspnea, anoxia, and foaming nasal discharge. Pathologic signs in animals that died following overdose of the plant included severe hydrothorax, generalized lung congestion, foamy exudate in bronchioles and trachea, epicardial and endocardial petechiation, and pericardial effusion in severely affected ewes. Microscopic lesions included a severe diffuse alveolar and interlobular edema. No significant alterations in blood constituents were observed in treated animals. Ewes administered the plant on several consecutive days developed an apparent adaptation to the toxin of the plant and were thereby able subsequently to tolerate levels 5-10 times the pre-treatment lethal dose with no discernible adverse clinical or pathological effects.
山羊豆（Galega officinalis L）是一种从欧洲引进的植物，在犹他州北部大量生长，对母羊（Ovis aries）进行了毒性测试。每天每千克体重摄入低至0.8克干燥植物所引发的中毒临床症状包括呼吸困难、缺氧和鼻腔泡沫状分泌物。过量摄入该植物后死亡的动物的病理症状包括严重胸腔积水、全身性肺充血、细支气管和气管内有泡沫状渗出物、严重受影响的母羊出现心外膜和心内膜瘀点以及心包积液。微观病变包括严重的弥漫性肺泡和小叶间水肿。在接受治疗的动物中未观察到血液成分有显著变化。连续几天给母羊投喂该植物后，它们对该植物毒素产生了明显的适应性，因此随后能够耐受比治疗前致死剂量高5至10倍的水平，且没有明显的不良临床或病理影响。
