Trościańczyk Aleksandra, Nowakiewicz Aneta, Kasela Martyna, Malm Anna, Tracz Anna Magdalena, Hahaj-Siembida Agata, Osińska Marcelina, Gula Szczepan, Jankowiak Igor
Sub-Department of Veterinary Microbiology, Department of Preclinical Veterinary Sciences, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland.
Department of Pharmaceutical Microbiology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
Antibiotics (Basel). 2023 Jun 30;12(7):1137. doi: 10.3390/antibiotics12071137.
is a drug resistant pathogen with zoonotic potential commonly isolated from humans and animals. The aim of this study was to compare the occurrence of drug resistance, resistance genes, sequence types (STs), and genotypes of isolated from humans, livestock, and wildlife in eastern Poland. A high percentage of isolates resistant to penicillin (63%), erythromycin (39%), clindamycin (37%), tetracycline (31%), and methicillin (MRSA-19%), an intermediate resistant to vancomycin (VISA-13%), and a multidrug resistant (MDR-39%) was obtained. Multilocus sequence typing analysis showed the presence of 35 different STs (with dominance ST 15, ST 45, ST 7, and ST 582 in human, and ST 398 and ST 8139 in porcine and cattle isolates, respectively), including 9 new ones that had never been reported before (ST 8133-8141). Identical genotypic patterns were detected among porcine and cattle isolates as well as from humans and cattle. A high percentage of MDR, MRSA, and VISA in humans and livestock combined with the presence of the same genotypes among isolated from human and cattle indicates the circulation of strains common in the region and their zoonotic potential. There is a need to develop new strategies to counteract this phenomenon according to the One Health policy.
是一种具有人畜共患病潜力的耐药病原体，通常从人和动物中分离得到。本研究的目的是比较波兰东部从人、家畜和野生动物中分离出的[病原体名称未给出]的耐药性、耐药基因、序列类型（STs）和基因型的发生情况。获得了高比例对青霉素耐药（63%）、红霉素耐药（39%）、克林霉素耐药（37%）、四环素耐药（31%）和耐甲氧西林（耐甲氧西林金黄色葡萄球菌-19%）的分离株，对万古霉素中介耐药（耐万古霉素金黄色葡萄球菌-13%），以及多重耐药（MDR-39%）的分离株。多位点序列分型分析显示存在35种不同的STs（在人类中优势ST为15、45、7和582，在猪和牛分离株中分别为398和8139），包括9种以前从未报道过的新STs（8133-8141）。在猪和牛分离株之间以及人与牛之间检测到相同的基因型模式。人与家畜中高比例的MDR、耐甲氧西林金黄色葡萄球菌和耐万古霉素金黄色葡萄球菌，以及从人和牛分离出的[病原体名称未给出]中存在相同基因型，表明该地区常见菌株的传播及其人畜共患病潜力。根据“同一健康”政策，需要制定新的策略来应对这一现象。
