Mladenova Irena
Department of Hygiene, Epidemiology, Microbiology, Parasitology and Infectious Diseases, Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
Antibiotics (Basel). 2023 Jul 13;12(7):1184. doi: 10.3390/antibiotics12071184.
() is the most common bacterial infection worldwide and one of the main etiological factors of chronic gastritis, peptic ulcer disease, and stomach neoplasms. The mass application of antibiotics without testing, especially during the last years of the pandemic of SARS-CoV-2, could lead to a dramatic increase in antibiotic resistance and reduced effectiveness of eradication regimens for infection. The epidemiology of resistance to antibiotics still has unclear mechanisms. Antibiotic policy should be intensified to optimize treatment, and regular monitoring of resistance of in different geographical regions should be conducted. Individualized treatment according to susceptibility testing is strongly advisable, and the best treatment regimens should be selected. The mutations in the genes encoding the antibiotic target protein are significant risk factors for resistance. Iatrogenic errors in diagnosis and prescribing treatment for the failure of eradication are other important risk factors. The low level of awareness and compliance with the correct treatment influence the rate of resistance. Epidemiological surveillance of antibiotic resistance and the adoption of new treatment strategies are needed. The discovery of an efficient vaccine against could reduce the pressure of the world's growing antibiotic resistance.
（某种细菌）是全球最常见的细菌感染，也是慢性胃炎、消化性溃疡病和胃部肿瘤的主要病因之一。未经检测就大量使用抗生素，尤其是在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的最后几年，可能导致抗生素耐药性急剧增加，以及该细菌感染根除方案的有效性降低。该细菌对抗生素的耐药性流行病学机制仍不明确。应加强抗生素政策以优化治疗，并对不同地理区域的该细菌耐药性进行定期监测。强烈建议根据药敏试验进行个体化治疗，并应选择最佳治疗方案。编码抗生素靶蛋白的基因中的突变是该细菌耐药的重要危险因素。因该细菌根除失败而导致的诊断和处方治疗方面的医源性错误是其他重要危险因素。对正确治疗的认识水平低和依从性差会影响该细菌的耐药率。需要对抗生素耐药性进行流行病学监测并采用新的治疗策略。发现一种针对该细菌的有效疫苗可以减轻全球日益增长的抗生素耐药性压力。
