Baus-Domínguez María, Bakkali Sara, Hermida-Cabrera Paula, Serrera-Figallo María-Angeles, Gutiérrez-Pérez José-Luis, Torres-Lagares Daniel
Departamento de Estomatología, Facultad de Odontología, Universidad de Sevilla, 41009 Sevilla, Spain.
Hospital Universitario Virgen del Rocío, Universidad de Sevilla, 41013 Sevilla, Spain.
Antibiotics (Basel). 2023 Jul 24;12(7):1223. doi: 10.3390/antibiotics12071223.
(1) Background: Given the existing controversy regarding the use of antibiotics in the treatment of peri-implantitis, this systematic review and meta-analysis aim to ascertain how beneficial the role of systemic and local antibiotics is in peri-implant surgical therapy, considering the harmful effects that they represent and the abuse of antibiotics in terms of global health. (2) Methods: To determine the therapeutic efficacy of the administration of antibiotics in the surgical treatment of peri-implantitis in terms of probing pocket depth (PPD) and bleeding on probing (BoP), electronic and manual bibliographic searches were carried out in the Embase and PubMed databases, collecting data that related to before and after treatment. (3) Results: The adjunctive use of local antibiotics provides significant improvements in PPD (MD = 1.29; 95% CI: 0.56 to 2.02; ≤ 0.0006; I = 0%) when compared with surgical treatment alone. No significant differences were found in the other subgroup; that is, the use of systemic antibiotics did not significantly improve PPD changes in the surgical treatment of peri-implantitis (MD = 0.40; 95% CI: -0.15 to 0.95; = 0.15; I = 0). (4) Conclusions: The use of local antibiotics in the surgical treatment of peri-implantitis seems to offer treatment improvements in terms of PPD and BoP, unlike that observed with the use of systemic antibiotics. However, these results should be taken with caution as they also depend on the type of surgical technique used, whether regenerative or resective. More research is needed on this topic to understand the role of local and systemic antibiotics in the treatment of peri-implantitis.
（1）背景：鉴于在种植体周围炎治疗中使用抗生素存在争议，本系统评价和荟萃分析旨在确定全身和局部应用抗生素在种植体周围手术治疗中的益处，同时考虑到它们所带来的有害影响以及在全球健康方面抗生素的滥用情况。（2）方法：为了确定抗生素给药在种植体周围炎手术治疗中对探诊深度（PPD）和探诊出血（BoP）的治疗效果，在Embase和PubMed数据库中进行了电子和手工文献检索，收集治疗前后相关数据。（3）结果：与单纯手术治疗相比，局部应用抗生素辅助治疗在PPD方面有显著改善（MD = 1.29；95%CI：0.56至2.02；P≤0.0006；I² = 0%）。在其他亚组中未发现显著差异；即全身应用抗生素在种植体周围炎手术治疗中对PPD变化没有显著改善（MD = 0.40；95%CI：-0.15至0.95；P = 0.15；I² = 0）。（4）结论：与全身应用抗生素不同，在种植体周围炎手术治疗中局部应用抗生素似乎在PPD和BoP方面能改善治疗效果。然而，这些结果应谨慎看待，因为它们还取决于所采用的手术技术类型，无论是再生性还是切除性的。关于这一主题需要更多研究以了解局部和全身应用抗生素在种植体周围炎治疗中的作用。
