Genizi Jacob, Berger Lotan, Mahajnah Muhammad, Shlonsky Yulia, Golan-Shany Orit, Romem Azriel, Halevy Ayelet, Nathan Keren, Sharkia Rajech, Zalan Abdelnaser, Kessel Aharon, Cohen Rony
Pediatric Department, Bnai Zion Medical Center, Haifa 3104802, Israel.
Bruce Rappaport Faulty of Medicine, Technion, Haifa 3109601, Israel.
Children (Basel). 2023 Jun 28;10(7):1122. doi: 10.3390/children10071122.
Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a prospective, cross-sectional study at three centers in Israel, we analyzed cerebrospinal fluid (CSF) samples from 60 children aged 0.5-18 years, including 43 children with a definitive diagnosis of PTC and a control group of 17 children. Levels of IL-4, IL-10, IL-17, CCL2, CCL7, CCL8, CCL13, BDNF, and IFN-γ were measured using ELISA kits. Levels of CCL2 were significantly higher in the PTC group compared to the control group ( < 0.05), with no other significant differences in the measured cytokines between the two groups. The groups did not differ significantly in clinical presentation, imaging, treatment, or ophthalmic findings. Our findings provide preliminary evidence that CCL2 may be involved in the pathogenesis of PTC and may serve a potential target for therapy in PTC.
假性脑瘤（PTC）是一种在无结构性病变或其他可识别病因的情况下以颅内压升高为特征的病症。细胞因子参与免疫反应和炎症的调节，已被认为与PTC的发病机制有关。在以色列三个中心进行的一项前瞻性横断面研究中，我们分析了60名年龄在0.5至18岁儿童的脑脊液（CSF）样本，其中包括43名确诊为PTC的儿童和17名儿童组成的对照组。使用酶联免疫吸附测定试剂盒测量白细胞介素-4（IL-4）、白细胞介素-10（IL-10）、白细胞介素-17（IL-17）、趋化因子配体2（CCL2）、趋化因子配体7（CCL7）、趋化因子配体8（CCL8）、趋化因子配体13（CCL13）、脑源性神经营养因子（BDNF）和干扰素-γ（IFN-γ）的水平。与对照组相比，PTC组中CCL2的水平显著更高（<0.05），两组间所测细胞因子的其他方面无显著差异。两组在临床表现、影像学、治疗或眼科检查结果方面无显著差异。我们的研究结果提供了初步证据，表明CCL2可能参与PTC的发病机制，并且可能成为PTC治疗的潜在靶点。
