Zhang Caixia, Zhang Hua, Tang Qingping, Zhang Junyi, Wang Shuo, Xie Zhihai, Jiang Weihong
Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, China.
Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha 410008, China.
Children (Basel). 2023 Jul 12;10(7):1207. doi: 10.3390/children10071207.
(1) Background: The recurrence rate of childhood recurrent sinusitis varies widely between 12% and 50%, with the postoperative recurrence risk factors remaining largely unidentified. We sought to enhance the understanding of chronic rhinosinusitis (CRS) via a retrospective observational childhood cohort. (2) Methods: The study recruited 125 cases. Demographic data and univariate and multivariate logistic regression analyses were conducted to investigate potential risk factors of childhood recurrent sinusitis following functional endoscopic sinus surgery (FESS). (3) Results: A postoperative recurrence rate of 21.6% was determined. Among the participants, 21 cases presented a history of allergic rhinitis (AR), with the remaining 104 cases being AR-free. A significantly heightened recurrence rate was noted in those bearing a history of AR compared to their counterparts devoid of such history ( < 0.000). The fully adjusted logistic regression model indicated a 21.04-fold increased risk of postoperative recurrence in childhood CRS bearing a history of AR compared to those without an AR history ( = 0.000), highlighting the history of AR as an independent risk factor for postoperative childhood recurrent sinusitis ( = 0.001); (4) Conclusions: The data implicate AR as an independent risk factor for postoperative childhood recurrent sinusitis.
(1) 背景：儿童复发性鼻窦炎的复发率在12%至50%之间差异很大，术后复发的危险因素在很大程度上仍不明确。我们试图通过一项回顾性观察性儿童队列研究来加深对慢性鼻-鼻窦炎（CRS）的理解。(2) 方法：该研究招募了125例病例。进行了人口统计学数据以及单变量和多变量逻辑回归分析，以调查功能性鼻内镜鼻窦手术（FESS）后儿童复发性鼻窦炎的潜在危险因素。(3) 结果：确定术后复发率为21.6%。在参与者中，21例有过敏性鼻炎（AR）病史，其余104例无AR病史。与无AR病史的参与者相比，有AR病史的参与者复发率显著升高（<0.000）。完全调整后的逻辑回归模型表明，有AR病史的儿童CRS术后复发风险比无AR病史的儿童高21.04倍（=0.000），突出了AR病史是儿童术后复发性鼻窦炎的独立危险因素（=0.001）；(4) 结论：数据表明AR是儿童术后复发性鼻窦炎的独立危险因素。
