不同形式大脑中动脉闭塞性缺血性中风的动物模型
Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion.
作者信息
Zeng Lang, Hu Shengqi, Zeng Lingcheng, Chen Rudong, Li Hua, Yu Jiasheng, Yang Hongkuan
机构信息
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, China.
出版信息
Brain Sci. 2023 Jun 29;13(7):1007. doi: 10.3390/brainsci13071007.
Abstract
Ischemic stroke is a common type of stroke that significantly affects human well-being and quality of life. In order to further characterize the pathophysiology of ischemic stroke and develop new treatment strategies, ischemic stroke models with controllable and consistent response to potential clinical treatments are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used animal model of ischemic stroke. This review discusses various methods for constructing the MCAO model and compares their advantages and disadvantages in order to provide better approaches for studying ischemic stroke.
摘要
缺血性中风是一种常见的中风类型，严重影响人类健康和生活质量。为了进一步阐明缺血性中风的病理生理学并开发新的治疗策略，迫切需要建立对潜在临床治疗有可控且一致反应的缺血性中风模型。大脑中动脉闭塞（MCAO）模型是目前缺血性中风最广泛使用的动物模型。本文综述了构建MCAO模型的各种方法，并比较了它们的优缺点，以便为研究缺血性中风提供更好的方法。
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Front Immunol. 2022 Jan 31;12:813536. doi: 10.3389/fimmu.2021.813536. eCollection 2021.
2
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