Darquennes Gil, Wacquier Benjamin, Loas Gwenolé, Hein Matthieu
Service de Psychiatrie et Laboratoire du Sommeil, Hôpital Universitaire de Bruxelles, Université libre de Bruxelles (ULB), Route de Lennik, 808-1070 Anderlecht, Belgium.
Brain Sci. 2023 Jul 13;13(7):1065. doi: 10.3390/brainsci13071065.
Given the limited data available in the literature, the aim of this study was to investigate the potential role played by the temporal dynamics of anhedonia (lifelong anhedonia and recent changes in anhedonia) in the occurrence of suicidal ideations in major depressed subjects. The clinical data of 285 major depressed subjects recruited from the database of the Erasme Hospital Sleep Laboratory were analyzed. A score on item nine of the Beck Depression Inventory (BDI-II) ≥1 and/or an identification during the systematic psychiatric assessment were used to determine the presence of suicidal ideations. The association between anhedonia complaints (lifelong anhedonia and recent change in anhedonia) and suicidal ideations in major depressed subjects was assessed by logistic regression analyzes. The prevalence of suicidal ideations was 39.3% in our sample of major depressed subjects. After adjusting for the main confounding factors, multivariate logistic regression analysis demonstrated that unlike lifelong anhedonia, only recent changes in anhedonia were a risk factor for suicidal ideations in major depressed subjects. Given this potential involvement of the recent change in anhedonia in the occurrence of suicidal ideations in major depressed subjects, it seems essential to better identify and adequately manage this specific form of anhedonia in order to open new perspectives for the prevention of suicide in this particular sub-population.
鉴于文献中可用的数据有限，本研究的目的是调查快感缺失的时间动态（终身快感缺失和快感缺失的近期变化）在重度抑郁患者自杀观念发生中所起的潜在作用。对从伊拉斯谟医院睡眠实验室数据库招募的285名重度抑郁患者的临床数据进行了分析。使用贝克抑郁量表（BDI-II）第九项的得分≥1和/或在系统的精神科评估中的一项鉴定来确定自杀观念的存在。通过逻辑回归分析评估重度抑郁患者中快感缺失主诉（终身快感缺失和快感缺失的近期变化）与自杀观念之间的关联。在我们的重度抑郁患者样本中，自杀观念的患病率为39.3%。在对主要混杂因素进行调整后，多变量逻辑回归分析表明，与终身快感缺失不同，只有快感缺失的近期变化是重度抑郁患者自杀观念的一个危险因素。鉴于快感缺失的近期变化可能参与重度抑郁患者自杀观念的发生，似乎有必要更好地识别和充分管理这种特定形式的快感缺失，以便为预防这一特定亚人群的自杀开辟新的前景。
