Damodharan Sudarshawn, Puccetti Diane
Department of Pediatrics, Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, University of Wisconsin School of Medicine & Public Health, Madison, WI 53792, USA.
Brain Sci. 2023 Jul 21;13(7):1106. doi: 10.3390/brainsci13071106.
Pediatric central nervous system (CNS) tumors are the most common solid tumor in children, with the majority being glial in origin. These tumors are classified by the World Health Organization (WHO) as either being low grade (WHO grade 1 and 2) or high grade (WHO grade 3 and 4). Our knowledge of the molecular landscape of pediatric brain tumors has advanced over the last decade, which has led to newer categorizations along with an expansion of therapeutic targets and options. In this review, we will give an overview of common CNS tumors seen in children along with a focus on treatment options and future considerations.
小儿中枢神经系统（CNS）肿瘤是儿童最常见的实体瘤，大多数起源于神经胶质。这些肿瘤被世界卫生组织（WHO）分为低级别（WHO 1级和2级）或高级别（WHO 3级和4级）。在过去十年中，我们对小儿脑肿瘤分子格局的认识有了进展，这导致了新的分类以及治疗靶点和选择的扩展。在这篇综述中，我们将概述儿童常见的中枢神经系统肿瘤，并重点介绍治疗选择和未来的考虑因素。
