Xie Xinxin, Zhang Yi, Kong Qianqian, Huang Hao, Yu Zhiyuan, Luo Xiang, Qu Wensheng
Neurological Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan 430030, China.
Brain Sci. 2023 Jul 23;13(7):1117. doi: 10.3390/brainsci13071117.
Headaches are common after ischemic stroke (IS). Unlike primary headaches, headaches attributed to IS have specific clinical features. This review describes the epidemiology, clinical characteristics, risk factors, and influence of IS headaches. Previous reports were summarized to show the correlations between headaches and structural lesions in the cerebral cortex, subcortical white matter, deep gray matter nuclei, brainstem, and cerebellum. However, the substantial heterogeneity of IS, subjective evaluations of headaches, and inadequate cohort studies make it difficult to explore the pathophysiology of headaches attributed to IS. In our recommendation, favorable imaging techniques, such as magnetic resonance imaging and positron emission tomography, may provide new insights into mechanical studies of IS headaches from structure to function. It may also be helpful to extend the research field by targeting several shared signal transducers between headaches and IS. These markers might be neuropeptides, vasoactive substances, ion channels, or electrophysiologic changes.
缺血性卒中（IS）后头痛很常见。与原发性头痛不同，归因于IS的头痛具有特定的临床特征。本综述描述了IS头痛的流行病学、临床特征、危险因素及影响。总结先前的报告以显示头痛与大脑皮层、皮层下白质、深部灰质核团、脑干和小脑结构病变之间的相关性。然而，IS的显著异质性、头痛的主观评估以及队列研究不足使得探究归因于IS的头痛的病理生理学变得困难。我们建议，诸如磁共振成像和正电子发射断层扫描等有利的成像技术可能会为从结构到功能的IS头痛的机制研究提供新的见解。通过针对头痛和IS之间的几种共享信号转导分子来扩展研究领域可能也会有所帮助。这些标志物可能是神经肽、血管活性物质、离子通道或电生理变化。
