Shin Hyeung-Seob, Shin Jae-Joon, Park Jeongkwang, Arab Imene, Suk Kyoungho, Lee Won-Ha
BK21 Plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Department of Pharmacology, Brain Science & Engineering Institute, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
Biomedicines. 2023 Jul 5;11(7):1905. doi: 10.3390/biomedicines11071905.
Long noncoding RNAs (lncRNAs) are molecules >200 bases in length without protein-coding functions implicated in signal transduction and gene expression regulation via interaction with proteins or RNAs, exhibiting various functions. The expression of lncRNAs has been detected in many cell types, including macrophages, a type of immune cell involved in acute and chronic inflammation, removal of dead or damaged cells, and tissue repair. Increasing evidence indicates that lncRNAs play essential roles in macrophage functions and disease development. Additionally, many animal studies have reported that blockage or modulation of lncRNA functions alleviates disease severity or morbidity rate. The present review summarizes the current knowledge regarding lncRNAs expressed in macrophages, focusing on their molecular targets and the biological processes regulated by them during the development of inflammatory diseases such as atherosclerosis and sepsis. Possible application of this information to lncRNA-targeting therapy is also discussed. The studies regarding macrophage lncRNAs described in this review can help provide valuable information for developing treatments for various pathological conditions involving macrophages.
长链非编码RNA（lncRNAs）是长度超过200个碱基且无蛋白质编码功能的分子，通过与蛋白质或RNA相互作用参与信号转导和基因表达调控，具有多种功能。lncRNAs已在许多细胞类型中被检测到，包括巨噬细胞，这是一种参与急性和慢性炎症、清除死亡或受损细胞以及组织修复的免疫细胞。越来越多的证据表明，lncRNAs在巨噬细胞功能和疾病发展中起重要作用。此外，许多动物研究报告称，lncRNA功能的阻断或调节可减轻疾病严重程度或发病率。本综述总结了目前关于巨噬细胞中表达的lncRNAs的知识，重点关注它们的分子靶点以及在动脉粥样硬化和败血症等炎症性疾病发展过程中由它们调节的生物学过程。还讨论了这些信息在lncRNA靶向治疗中的可能应用。本综述中描述的关于巨噬细胞lncRNAs的研究有助于为开发针对涉及巨噬细胞的各种病理状况的治疗方法提供有价值的信息。
