College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China.
Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.
Genes (Basel). 2023 Jul 4;14(7):1398. doi: 10.3390/genes14071398.
As an environmentally-friendly agent, slightly acidic electrolyzed water (SAEW) was introduced in drinking water of newly weaned piglets for diarrhea prevention. In total, 72 piglets were employed and 3% SAEW was added into the normal temperature and warm (30 °C) tap water, respectively, for this 33-day feeding experiment. It was found that the total bacteria and coliforms in the drinking water were reduced by 70% and 100%, respectively, with the addition of 3% SAEW. After SAEW treatment, the average daily water and feed intakes of piglets were increased during the first 16 days, and the diarrhea rate was reduced by 100%, with not one case of diarrhea recorded at the end of the experiment. The microbiome results demonstrated that SAEW decreased the diversity of caecum bacteria with normal tap water supplied, and increased the richness of the caecum bacteria with warm tap water supplied. SAEW also increased the abundance of potentially beneficial genera and and reduced the abundance of pathogenic . Moreover, twelve metabolic functions belonging to the cluster of metabolism and organismal functions, including digestion and the endocrine and excretory systems, were greatly enhanced. Correlation analysis indicated that the influence of intestinal pathogens on water and feed intakes and the diarrhea of piglets were decreased by SAEW. The results suggest that SAEW can be used as an antibiotic substitute to prevent diarrhea in newly weaned piglets.
作为一种环保型试剂，微酸性电解水（SAEW）被应用于预防断奶仔猪腹泻的饮用水中。在这项为期 33 天的喂养实验中，共有 72 头仔猪参与，分别在常温水和温水（30°C）中添加 3%的 SAEW。结果发现，添加 3%的 SAEW 后，饮用水中的总细菌和大肠菌群分别减少了 70%和 100%。经过 SAEW 处理后，仔猪在前 16 天的日均饮水量和采食量增加，腹泻率降低 100%，实验结束时无一例腹泻。微生物组结果表明，SAEW 降低了正常自来水供应下盲肠细菌的多样性，并增加了温水供应下盲肠细菌的丰富度。SAEW 还增加了潜在有益菌属 和 的丰度，降低了致病性菌属 的丰度。此外，12 种代谢功能（属于代谢和机体功能簇）也得到了极大的增强，包括消化、内分泌和排泄系统。相关性分析表明，SAEW 降低了肠道病原体对仔猪饮水量、采食量和腹泻的影响。这些结果表明，SAEW 可以作为抗生素替代品，预防断奶仔猪腹泻。
