从奥米克戎分层到结直肠癌的个体化医学：未来之路。

From Omic Layers to Personalized Medicine in Colorectal Cancer: The Road Ahead.

机构信息

Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (Universidad del País Vasco/Euskal Herriko Unibertsitatea), 48940 Leioa, Spain.

Biodonostia, Gastrointestinal Genetics Group, 20014 San Sebastián, Spain.

出版信息

Genes (Basel). 2023 Jul 11;14(7):1430. doi: 10.3390/genes14071430.

DOI:10.3390/genes14071430

PMID:37510334

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379575/

Abstract

Colorectal cancer is a major health concern since it is a highly diagnosed cancer and the second cause of death among cancers. Thus, the most suitable biomarkers for its diagnosis, prognosis, and treatment have been studied to improve and personalize the prevention and clinical management of colorectal cancer. The emergence of omic techniques has provided a great opportunity to better study CRC and make personalized medicine feasible. In this review, we will try to summarize how the analysis of the omic layers can be useful for personalized medicine and the existing difficulties. We will discuss how single and multiple omic layer analyses have been used to improve the prediction of the risk of CRC and its outcomes and how to overcome the challenges in the use of omic layers in personalized medicine.

摘要

结直肠癌是一个主要的健康关注点，因为它是一种高度诊断的癌症，也是癌症死亡的第二大原因。因此，已经研究了最适合其诊断、预后和治疗的生物标志物，以改善和个性化结直肠癌的预防和临床管理。组学技术的出现为更好地研究 CRC 并使个性化医学成为可能提供了巨大的机会。在这篇综述中，我们将尝试总结分析组学层如何有助于个性化医学和现有的困难。我们将讨论如何使用单一和多种组学层分析来提高 CRC 风险及其结果的预测，以及如何克服个性化医学中使用组学层的挑战。