D-二聚体、C 反应蛋白和铁蛋白与孕妇 COVID-19 严重程度的相关性：巴西北部一项横断面研究的重要发现。
Association of D-Dimer, C-Reactive Protein, and Ferritin with COVID-19 Severity in Pregnant Women: Important Findings of a Cross-Sectional Study in Northern Brazil.
机构信息
Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belém 66075-110, PA, Brazil.
Virology Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
出版信息
Int J Environ Res Public Health. 2023 Jul 20;20(14):6415. doi: 10.3390/ijerph20146415.
BACKGROUND
The COVID-19 pandemic has had a great impact on pregnant women due to the broad clinical spectrum of the disease. The present study investigated the profile of three biomarkers during hospital admission of pregnant women-D-dimer, C-reactive protein (CRP), and ferritin-and their correlation with the severity and outcome of COVID-19.
METHODS
The cross-sectional study included 226 pregnant women hospitalized in the city of Belém, Pará, Northern Brazil, from April 2020 to July 2021. Epidemiological and laboratory data were obtained from medical records, and all pregnant women underwent RT-PCR molecular testing for the detection of SARS-CoV-2.
RESULTS
In total, 121 (53.5%) were positive and 105 (46.5%) were negative for SARS-CoV-2 using RT-PCR. Most pregnant women (49.5%) with COVID-19 were between 26 and 34 years old, were residing in the interior of the state of Pará (51.2%), and were in the third gestational trimester (71.9%). In addition, 71.1% of them were admitted to the ward and 28.9% were admitted to the intensive care unit (ICU), with 90.9% surviving COVID-19. The concentrations of D-dimer ( = 0.0122) and ferritin ( ≤ 0.0001) were significantly higher among pregnant women with COVID-19, especially among those hospitalized in the ICU.
CONCLUSION
Ferritin and D-dimer seem to serve as important biomarkers for the prognosis of COVID-19 in pregnant women, which was not observed for CRP.
背景
由于 COVID-19 疾病的广泛临床谱，该疾病对孕妇产生了巨大影响。本研究调查了住院孕妇的三种生物标志物-D-二聚体、C 反应蛋白（CRP）和铁蛋白的特征及其与 COVID-19 严重程度和结局的相关性。
方法
这项横断面研究纳入了 2020 年 4 月至 2021 年 7 月在巴西北部帕拉州贝伦市住院的 226 名孕妇。从病历中获取了流行病学和实验室数据，所有孕妇均接受了 SARS-CoV-2 的 RT-PCR 分子检测。
结果
共有 121 名（53.5%）孕妇的 RT-PCR 检测结果为 SARS-CoV-2 阳性，105 名（46.5%）为阴性。大多数 COVID-19 孕妇（49.5%）年龄在 26 至 34 岁之间，居住在帕拉州内陆地区（51.2%），处于妊娠晚期（71.9%）。此外，71.1%的孕妇入住病房，28.9%入住重症监护病房（ICU），90.9%存活。COVID-19 孕妇的 D-二聚体（ = 0.0122）和铁蛋白浓度（ ≤ 0.0001）显著升高，尤其是 ICU 住院孕妇。
结论
铁蛋白和 D-二聚体似乎是预测 COVID-19 孕妇预后的重要生物标志物，而 CRP 则不然。
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