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米克微型皮肤移植术与脱细胞真皮基质在儿科患者中的应用:一种治疗大面积外渗性损伤的新方法

Meek Micro-Skin Grafting and Acellular Dermal Matrix in Pediatric Patients: A Novel Approach to Massive Extravasation Injury.

作者信息

Maruccia Michele, Tedeschi Pasquale, Corrao Claudia, Elia Rossella, La Padula Simone, Di Summa Pietro G, Maggio Giulio M M, Giudice Giuseppe

机构信息

Division of Plastic and Reconstructive Surgery, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, Piazza Giulio Cesare, 70121 Bari, Italy.

Department of Plastic and Reconstructive Surgery, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.

出版信息

J Clin Med. 2023 Jul 10;12(14):4587. doi: 10.3390/jcm12144587.

Abstract

(1) Background: Extravasation injuries in pediatric patients can lead to significant harm if they are not promptly diagnosed and treated. However, evidence-based standardization on extravasation management remains limited, particularly for extensive wound necrosis. This case report presents the management of an 8-week-old premature patient with an extensive extravasation injury involving the right forearm and dorsum of the hand. (2) Methods: The patient was evaluated by a multidisciplinary team in our Neonatal Intensive Care Unit. Surgical intervention involved the debridement of necrotic tissues, followed by temporary coverage with an acellular dermal matrix. Definitive coverage was achieved through Meek micrografting after three weeks. Physical therapy was provided with pre- and post-rehabilitation range of motion assessed using goniometric measurements. Scar quality was evaluated using the Vancouver Scar Scale. (3) Results: The engraftment rate of the Meek micrografts was 93%, with 16 out of 226 micrografts lost. The patient achieved a Vancouver Scar Scale score of 6, indicating a moderate degree of scarring. Significant improvements in elbow, wrist, and finger joint range of motion were observed at a 1-year follow-up. (4) Conclusions: Close observation and heightened awareness of extravasation risks by trained personnel are crucial. Meek micrografting combined with dermal substitute coverage represents an innovative approach to managing extravasation wounds in pediatric patients.

摘要

(1) 背景:小儿患者的外渗性损伤若未及时诊断和治疗,可能会导致严重伤害。然而,关于外渗管理的循证标准化仍然有限,尤其是对于广泛的伤口坏死。本病例报告介绍了一名8周大的早产患者的外渗性损伤的处理情况,该损伤累及右前臂和手背。(2) 方法:患者在我们的新生儿重症监护病房接受了多学科团队的评估。手术干预包括坏死组织清创,随后用脱细胞真皮基质进行临时覆盖。三周后通过米克微型植皮术实现确定性覆盖。提供物理治疗,并使用角度测量法评估康复前后的关节活动范围。使用温哥华瘢痕量表评估瘢痕质量。(3) 结果:米克微型植皮的成活率为93%,226个微型植皮中有16个丢失。患者的温哥华瘢痕量表评分为6分,表明瘢痕程度为中度。在1年随访时,观察到肘部、腕部和手指关节活动范围有显著改善。(4) 结论:训练有素的人员密切观察并提高对外渗风险的认识至关重要。米克微型植皮术与真皮替代物覆盖相结合是管理小儿患者外渗伤口的一种创新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d0c/10380205/bf7d33d36e11/jcm-12-04587-g001.jpg

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