Lopian Miriam, Kashani-Ligumsky Lior, Many Ariel
Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak 51544, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
J Clin Med. 2023 Jul 15;12(14):4701. doi: 10.3390/jcm12144701.
The decision to postpone parenting has gained momentum in recent years, a shift driven by evolving social dynamics and improved access to fertility treatments. Despite their increasing prevalence, pregnancies at advanced maternal ages are associated with increased risks of adverse maternal and neonatal outcomes. This article addresses the association between advanced maternal age and hypertensive disorders of pregnancies (HDPs), which are more prevalent and a significant cause of maternal morbidity and mortality in this population. This review explores the biological mechanisms and age-related risk factors that underpin this increased susceptibility and offers practical management strategies that can be implemented prior to, as well as during, each stage of pregnancy to mitigate the incidence and severity of HDPs in this group. Lastly, this review acknowledges both the short-term and long-term postpartum implications of HDPs in women of advanced maternal age.
近年来，推迟生育的决定愈发流行，这一转变是由不断演变的社会动态以及获得生育治疗的机会增加所驱动的。尽管高龄孕产妇的比例不断上升，但高龄妊娠与孕产妇和新生儿不良结局风险增加相关。本文探讨高龄孕产妇与妊娠期高血压疾病（HDPs）之间的关联，HDPs在该人群中更为普遍，是孕产妇发病和死亡的重要原因。本综述探讨了导致这种易感性增加的生物学机制和与年龄相关的风险因素，并提供了在妊娠各阶段之前以及期间可实施的实际管理策略，以降低该组人群中HDPs的发生率和严重程度。最后，本综述认识到HDPs对高龄孕产妇产后的短期和长期影响。
