Gwadera Łukasz, Białas Adam J, Kumor-Kisielewska Anna, Miłkowska-Dymanowska Joanna, Majewski Sebastian, Piotrowski Wojciech J
Department of Pneumology, Medical University of Lodz, 90-153 Lodz, Poland.
J Clin Med. 2023 Jul 18;12(14):4745. doi: 10.3390/jcm12144745.
Sarcoidosis is a systemic granulomatous disease with a variety of presentations. One of the known symptoms are altered vitamin D metabolism and hypercalcemia. In our study, we aimed to assess associations between disease activity, inflammatory parameters, and vitamin D and calcium status. The secondary aim was to find any dependencies between calcium and vitamin D metabolism and fatigue and quality of life in patients with sarcoidosis. We enrolled 58 patients with sarcoidosis (47 classified as active disease, 11 classified as non-active) and compared them with 25 healthy volunteers. Calcium concentration was significantly higher in the study group than in healthy controls. It correlated with some inflammatory markers but not with vitamin D status. Not calcium nor vitamin D, but phosphate concentration correlated with life quality was assessed with the use of the Sarcoidosis Health Questionnaire. An association between phosphate concentration and fatigue was also noted, but it did not reach statistical significance. Calcium concentration was higher in patients with sarcoidosis, but it was not an indicator of the disease activity, while phosphate concentration was significantly lower in patients with active sarcoidosis.
结节病是一种具有多种表现形式的全身性肉芽肿性疾病。已知症状之一是维生素D代谢改变和高钙血症。在我们的研究中，我们旨在评估疾病活动、炎症参数与维生素D及钙状态之间的关联。次要目标是找出结节病患者钙和维生素D代谢与疲劳及生活质量之间的任何相关性。我们招募了58例结节病患者（47例归类为活动性疾病，11例归类为非活动性疾病），并将他们与25名健康志愿者进行比较。研究组的钙浓度显著高于健康对照组。它与一些炎症标志物相关，但与维生素D状态无关。使用结节病健康问卷评估发现，与生活质量相关的不是钙也不是维生素D，而是磷酸盐浓度。还注意到磷酸盐浓度与疲劳之间存在关联，但未达到统计学意义。结节病患者的钙浓度较高，但它不是疾病活动的指标，而活动性结节病患者的磷酸盐浓度显著较低。
