Fujii Toshiya, Aoyama Norio, Kida Sayuri, Taniguchi Kentaro, Yata Tomomi, Minabe Masato, Komaki Motohiro
Department of Periodontology, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Kanagawa, Japan.
Bunkyou Dori Dental Clinic, 2-4-1 Anagawa, Chiba 263-0024, Chiba, Japan.
J Clin Med. 2023 Jul 18;12(14):4759. doi: 10.3390/jcm12144759.
A relationship between periodontitis and liver function has been suggested. Indeed, patients with severe periodontal disease have been found to be more prone to liver dysfunction. The periodontal inflammatory surface area (PISA) has been shown to be a useful indicator of periodontal and systemic diseases. However, little information is available regarding whether the PISA is associated with liver function markers, such as gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). This study aimed to clarify relationship between liver function markers, AST, ALT, and GGT, and PISA level in a cross-sectional study. The subjects were recruited between 2018 and 2021 at the Medical and Dental Collaboration Center of Kanagawa Dental College Hospital. A periodontal clinical examination was performed, and the PISA was calculated. Peripheral blood samples were collected, and serum levels of liver function markers were measured. The levels of liver function markers were examined in different values of PISA. Participants with high PISA scores were more likely to have increased GGT levels while AST and ALT were not changed with PISA. Increased GGT was found in 10.8% and 29.4% ( = 0.0056), increased AST in 48.2% and 52.9% ( = 0.62), and increased ALT in 35.2% and 47.0% ( = 0.20) among <300 mm and ≧300 mm PISA groups, respectively. It was found that males with a PISA of 300 mm or higher had an elevated level of serum GGT. In conclusion, elevated GGT was found in the high PISA group, particularly in males, while AST and ALT did not differ by PISA.
牙周炎与肝功能之间的关系已被提出。事实上，已发现患有严重牙周病的患者更容易出现肝功能障碍。牙周炎炎症表面积（PISA）已被证明是牙周病和全身性疾病的一个有用指标。然而，关于PISA是否与肝功能指标，如γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）相关的信息很少。本研究旨在通过一项横断面研究阐明肝功能指标AST、ALT和GGT与PISA水平之间的关系。研究对象于2018年至2021年在神奈川齿科大学医院的医学与牙科合作中心招募。进行了牙周临床检查，并计算了PISA。采集外周血样本，测量肝功能指标的血清水平。在不同PISA值下检查肝功能指标水平。PISA评分高的参与者更有可能出现GGT水平升高，而AST和ALT水平不受PISA影响。在PISA<300 mm和≧300 mm组中，GGT升高的比例分别为10.8%和29.4%（P = 0.0056），AST升高的比例分别为48.2%和52.9%（P = 0.62），ALT升高的比例分别为35.2%和47.0%（P = 0.20）。发现PISA为300 mm或更高的男性血清GGT水平升高。总之，在高PISA组中发现GGT升高，尤其是在男性中，而AST和ALT水平在不同PISA之间没有差异。
