Rowland I R, Mallett A K, Bearne C A, Farthing M J
Xenobiotica. 1986 Jun;16(6):519-23. doi: 10.3109/00498258609043540.
A comparison was made in six species of animal (rat, mouse, hamster, guinea-pig, marmoset and man) of five enzyme activities associated with the hindgut microflora. Marked differences were found in the caecal activities of azoreductase, beta-glucosidase, beta-glucuronidase, nitrate reductase and nitroreductase in the four rodents, with no one species exhibiting consistently higher or lower enzyme activity. None of the laboratory animals, including the marmoset, provided an approximation of the enzyme profile associated with human faecal flora. The results indicate that it may be invalid to extrapolate the results of bacterial metabolic studies between closely related species, or from animals to man.
对六种动物（大鼠、小鼠、仓鼠、豚鼠、狨猴和人类）中与后肠微生物群相关的五种酶活性进行了比较。在四种啮齿动物中，发现盲肠中偶氮还原酶、β-葡萄糖苷酶、β-葡萄糖醛酸酶、硝酸盐还原酶和硝基还原酶的活性存在显著差异，没有一个物种的酶活性始终较高或较低。包括狨猴在内的所有实验动物，都无法近似模拟与人类粪便菌群相关的酶谱。结果表明，在亲缘关系密切的物种之间，或从动物到人类推断细菌代谢研究结果可能是无效的。
