天然免疫蛋白 Tag7（PGLYRP1）的短肽通过 TNF 受体选择性诱导肿瘤细胞死亡的抑制或激活。
Short Peptides of Innate Immunity Protein Tag7 (PGLYRP1) Selectively Induce Inhibition or Activation of Tumor Cell Death via TNF Receptor.
机构信息
Institute of Gene Biology (RAS), Moscow 119334, Russia.
出版信息
Int J Mol Sci. 2023 Jul 12;24(14):11363. doi: 10.3390/ijms241411363.
In this study, we have found two peptides of Tag7 (PGLYRP1) protein-17.1A (HRDVQRT) and 17.1B (RSNYVLKG), that have different affinities to the TNFR1 receptor and the Hsp70 protein. Peptide 17.1A is able to inhibit signal transduction through the TNFR1 receptor, and peptide 17.1B can activate this receptor in a complex with Hsp70. Thus, it is possible to modulate the activity of the TNFR1 receptor and further perform its specific inhibition or activation in the treatment of various autoimmune or oncological diseases.
在这项研究中，我们发现了 Tag7（PGLYRP1）蛋白的两个肽段 17.1A（HRDVQRT）和 17.1B（RSNYVLKG），它们与 TNFR1 受体和 Hsp70 蛋白具有不同的亲和力。肽段 17.1A 能够抑制通过 TNFR1 受体的信号转导，而肽段 17.1B 可以与 Hsp70 形成复合物激活该受体。因此，有可能调节 TNFR1 受体的活性，并在治疗各种自身免疫或肿瘤疾病中进一步进行其特异性抑制或激活。
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