短肽如何与口腔细胞相互作用？一项系统综述。

How short peptides interact with oral cells? A systematic review.

作者信息

Tetè Giulia, Trofimov Aleksandr, Vinskid Natasha Cinta, Tafuri Giuseppe, Profili Fabia, Sinjari Bruna

机构信息

Department of Human Sciences, "Sustainable Blue Economy and One Health"-XL Cycle, Law, and Economics "Leonardo da Vinci", UNIDAV, Telematic University, Chieti, Torrevecchia Teatina, 66100, Italy.

Department of Innovative Technologies in Medicine and Dentistry, Unit of Prosthodontics, University "G. d'Annunzio" of Chieti-Pescara, Chieti, 66100, Italy.

出版信息

BMC Oral Health. 2025 Apr 7;25(1):494. doi: 10.1186/s12903-025-05856-z.

DOI:10.1186/s12903-025-05856-z

PMID:40197322

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11974078/

Abstract

BACKGROUND

The study of short peptides in dentistry is a particularly promising area, due to their unique biological properties, such as antibacterial and antitumor activity, the ability to modulate immune responses, tissue regeneration processes, and their potential to stimulate stem cell differentiation. This study provides a systematic review aimed at analyzing the role of short peptides in the pathogenesis and treatment of oral diseases.

METHODS

A systematic search was performed according to the PRISMA statement and employed the PICO(S) approach. The search was limited to English-language articles, and in vitro study were included in the electronic search. A comprehensive search was conducted across PubMed, Embase, Web of Science and Cochrane Library databases, without timeframe limits, resulting in a total of 1085 scientific articles. After duplicate removal, 563 unique papers remained for further analysis. Following this screening process, 19 studies were identified as relevant to the topic. A final selection of 9 scientific papers was made based on their study type and the specific peptide examined. One last article was eliminated in final analysis because the laboratory methodology is now refuted by more recent scientific evidence.

RESULTS

8 in vitro studies dealing with different short peptides with different biological functions against oral cavity cells and tissues were included. 4 articles highlighted the ability of short peptides to positively influence the proliferation of cells in the oral cavity. 2 articles highlighted the antitumour activity of short peptides. 1 article highlighted the antimicrobial activity of the peptide DJK-15. The last paper showed that Pep-B has anti-inflammatory properties towards the cells of the oral cavity.

CONCLUSIONS

However, the main short peptides that have been tested in vitro and that act on cells and tissues of the oral cavity are the focus of this systematic review. It can therefore be used as a basis for a possible hypothesis of new in vitro studies to compare the different molecules, for new in vivo studies and for the investigation of potential action mechanisms and applications for new drugs to combat diseases of the oral cavity.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

由于短肽具有独特的生物学特性，如抗菌和抗肿瘤活性、调节免疫反应的能力、组织再生过程以及刺激干细胞分化的潜力，牙科领域对短肽的研究是一个特别有前景的领域。本研究提供了一项系统综述，旨在分析短肽在口腔疾病发病机制和治疗中的作用。

方法

根据PRISMA声明进行系统检索，并采用PICO(S)方法。检索仅限于英文文章，电子检索纳入体外研究。对PubMed、Embase、Web of Science和Cochrane图书馆数据库进行了全面检索，无时间限制，共获得1085篇科学文章。去除重复项后，剩余563篇独特论文进行进一步分析。经过筛选过程，确定了19项与该主题相关的研究。根据研究类型和所检测的特定肽，最终选择了9篇科学论文。在最终分析中，由于该实验室方法现在已被最新科学证据推翻，因此排除了最后一篇文章。