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对扇贝衍生羟磷灰石吸附的抑制作用。

Inhibitory Effect of Adsorption of onto Scallop-Derived Hydroxyapatite.

机构信息

Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

Department of Oral & Maxillofacial Oncology and Surgery, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.

出版信息

Int J Mol Sci. 2023 Jul 12;24(14):11371. doi: 10.3390/ijms241411371.

DOI:10.3390/ijms241411371
PMID:37511130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10379008/
Abstract

Hydroxyapatite adsorbs various substances, but little is known about the effects on oral bacteria of adsorption onto hydroxyapatite derived from scallop shells. In the present study, we analyzed the effects of adsorption of onto scallop-derived hydroxyapatite. When scallop-derived hydroxyapatite was mixed with , a high proportion of the bacterial cells adsorbed onto the hydroxyapatite in a time-dependent manner. An RNA sequencing analysis of adsorbed onto hydroxyapatite showed that the upregulation of genes resulted in abnormalities in pathways involved in glycogen and histidine metabolism and biosynthesis compared with cells in the absence of hydroxyapatite. adsorbed onto hydroxyapatite was not killed, but the growth of the bacteria was inhibited. Electron microscopy showed morphological changes in cells adsorbed onto hydroxyapatite. Our results suggest that hydroxyapatite derived from scallop shells showed a high adsorption ability for . This hydroxyapatite also caused changes in gene expression related to the metabolic and biosynthetic processes, including the glycogen and histidine of , which may result in a morphological change in the surface layer and the inhibition of the growth of the bacteria.

摘要

羟磷灰石吸附各种物质，但对于从扇贝壳中提取的羟磷灰石吸附对口腔细菌的影响知之甚少。在本研究中，我们分析了吸附到扇贝衍生羟磷灰石上的影响。当将羟磷灰石与混合时，细菌细胞的很大一部分以时间依赖性方式吸附到羟磷灰石上。对吸附到羟磷灰石上的基因的 RNA 测序分析表明，与没有羟磷灰石的细胞相比，与糖原和组氨酸代谢和生物合成途径相关的基因上调导致异常。吸附到羟磷灰石上的并没有死亡，但细菌的生长受到抑制。电子显微镜显示吸附到羟磷灰石上的细胞形态发生变化。我们的结果表明，从扇贝壳中提取的羟磷灰石对表现出很高的吸附能力。这种羟磷灰石还导致与代谢和生物合成过程相关的基因表达发生变化，包括和组氨酸，这可能导致表面层的形态变化和细菌生长的抑制。

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