Immunology of Infectious Diseases Laboratory, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa 58051-900, PB, Brazil.
Int J Mol Sci. 2023 Jul 13;24(14):11385. doi: 10.3390/ijms241411385.
complex causes tuberculosis (TB), a disease that causes pulmonary inflammation but can also affect other tissues. Despite macrophages having a defined role in TB immunopathogenesis, other innate immune cells, such as neutrophils, are involved in this process. These cells have high phagocytic ability and a microbial-killing machine comprised of enzymes, antimicrobial peptides, and reactive oxygen species. In the last two decades, a new neutrophil immune response, the neutrophil extracellular traps (NETs), has been intensely researched. NETs comprise DNA associated with histones, enzymes, and antimicrobial peptides. These structures are related to antimicrobial immune response and some immuno-pathogenesis mechanisms. This mini review highlights the role of NETs in tuberculosis and how they can be helpful as a diagnostic tool and/or therapeutic target.
复杂原因导致结核病（TB），这是一种引起肺部炎症的疾病，但也可能影响其他组织。尽管巨噬细胞在结核病发病机制中具有明确的作用，但其他先天免疫细胞，如中性粒细胞，也参与了这一过程。这些细胞具有高吞噬能力和由酶、抗菌肽和活性氧组成的微生物杀伤机器。在过去的二十年中，一种新的中性粒细胞免疫反应——中性粒细胞胞外陷阱（NETs）得到了深入研究。NETs 由与组蛋白、酶和抗菌肽相关的 DNA 组成。这些结构与抗菌免疫反应和一些免疫发病机制有关。这篇小型综述强调了 NETs 在结核病中的作用，以及它们如何作为一种诊断工具和/或治疗靶点具有帮助。
