Department of Navy Environmental and Occupational Health, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China.
Department of Pathophysiology, College of Basic Medical Sciences, Naval Medical University, Shanghai 200433, China.
Int J Mol Sci. 2023 Jul 13;24(14):11415. doi: 10.3390/ijms241411415.
FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in cancer development, although its prognostic function remains controversial. In this study, we analyzed the expression of FKBP10 in tumor tissues using online databases (TCGA) as well as our CRC cohort, and investigated the relationship between its subcellular expression pattern and patient outcomes. Cox regression analysis was used to determine the associations between different subcellular expression patterns of FKBP10 and clinical features of patients. We also discussed the expression level of FKBP10 based on different subcellular expression patterns. Our results showed that FKBP10 was significantly elevated in CRC tissues and exhibited three different subcellular expression patterns which were defined as 'FKBP10-C' (concentrated), 'FKBP10-T' (transitional) and 'FKBP10-D' (dispersive). The FKBP10-D expression pattern was only found in tumor tissues and was associated with unfavorable disease-free survival in CRC patients. High expression levels of FKBP10-C predicted an unfavorable prognosis of recurrence of CRC, while FKBP10-D did not. Our findings suggest that the subcellular expression patterns and expression level of FKBP10 play crucial prognostic roles in CRC, which revealed that FKBP10 may be a viable prognostic and therapeutic target for the diagnosis and treatment of CRC.
FKBP10 是 FK506 结合蛋白（FKBP）家族的一员，其与癌症的发生发展有关，但其预后功能仍存在争议。在本研究中，我们使用在线数据库（TCGA）和我们的 CRC 队列分析了肿瘤组织中 FKBP10 的表达，并研究了其亚细胞表达模式与患者结局之间的关系。Cox 回归分析用于确定 FKBP10 的不同亚细胞表达模式与患者临床特征之间的关联。我们还根据不同的亚细胞表达模式讨论了 FKBP10 的表达水平。研究结果表明，FKBP10 在 CRC 组织中明显上调，并表现出三种不同的亚细胞表达模式，分别定义为'FKBP10-C'（集中）、'FKBP10-T'（过渡）和'FKBP10-D'（弥散）。'FKBP10-D'表达模式仅在肿瘤组织中发现，与 CRC 患者无病生存不良相关。FKBP10-C 的高表达预示着 CRC 复发的预后不良，而 FKBP10-D 则不然。研究结果表明，FKBP10 的亚细胞表达模式和表达水平在 CRC 中具有重要的预后作用，提示 FKBP10 可能是 CRC 诊断和治疗的一个有前途的预后和治疗靶点。
