Okatan Derya Öztürk, Okatan Ali Ertan, Hancı Hatice, Demir Selim, Yaman Serap Özer, Çolakoğlu Serdar, Odacı Ersan
1 Department of IVF, Etlik Zübeyde Hanım Women's Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
2 Department of Urology, Fatih State Hospital, University of Health Sciences, Trabzon, Turkey.
Toxicol Ind Health. 2018 Oct;34(10):693-702. doi: 10.1177/0748233718781292. Epub 2018 Jul 15.
The effect of the electromagnetic field (EMF) established when cell phones are in use on human health, and particularly the head, has been the subject of major scientific research. Phones are usually carried near the lumbar region when not in use, and the kidneys will also inevitably be affected by such fields. We investigated the effects on the kidneys of female rats exposed to a continuous 900-megahertz (MHz) EMF for 1 h daily in mid-late adolescence. Control, sham, and EMF groups were established. The EMF was applied to the application group rats daily on postnatal days 35-59. A pseudo-megahertz effect was applied to sham group rats. All animals were euthanized on postnatal day 60. Right kidney tissues were subjected to routine procedures. Malondialdehyde, total antioxidant status, and total oxidant status (TOS) were investigated in left kidneys, and the oxidative stress index (OSI) was also calculated from these. Histopathological analysis revealed no pathology in either the control or sham groups. However, findings including hemorrhage in glomerulus, vacuolization and irregularity in the proximal and distal tubular epithelium, diffuse glomerular degeneration and edema, occasional degeneration in Bowman capsules, hemorrhage in the medullary region, disturbed nucleus location and morphology, and tubular edema in the cortex were observed in the EMF groups. TOS and OSI values were lower in the EMF group (9.4316 ± 1.0211 and 0.8461 ± 0.0826, respectively) and the sham group (8.2171 ± 0.6437 and 0.7358 ± 0.0545, respectively) than in the control group (11.1522 ± 1.3389 and 1.0085 ± 0.1174, respectively) ( p < 0.05). In conclusion, exposure to a continuous 900-MHz EMF for 1 h daily during middle and late adolescence may cause various changes in the female rat kidney at postnatal day 60.
手机使用时所产生的电磁场（EMF）对人体健康尤其是头部的影响，一直是重大科学研究的课题。手机不使用时通常放在腰部附近，肾脏也不可避免地会受到此类电磁场的影响。我们研究了青春期中后期的雌性大鼠每天暴露于连续900兆赫兹（MHz）的电磁场1小时对肾脏的影响。设立了对照组、假处理组和电磁场组。在出生后第35 - 59天，每天对应用组大鼠施加电磁场。对假处理组大鼠施加伪兆赫兹效应。所有动物在出生后第60天安乐死。对右肾组织进行常规处理。对左肾进行丙二醛、总抗氧化状态和总氧化状态（TOS）检测，并据此计算氧化应激指数（OSI）。组织病理学分析显示，对照组和假处理组均无病变。然而，在电磁场组中观察到了包括肾小球出血、近端和远端肾小管上皮细胞空泡化和不规则、弥漫性肾小球变性和水肿、鲍曼囊偶尔变性、髓质区域出血、细胞核位置和形态紊乱以及皮质肾小管水肿等情况。电磁场组（分别为9.4316±1.0211和0.8461±0.0826）和假处理组（分别为8.2171±0.6437和0.7358±0.0545）的TOS和OSI值均低于对照组（分别为11.1522±1.3389和1.0085±0.1174）（p<0.05）。总之，青春期中后期每天暴露于连续900 - MHz的电磁场1小时，可能会在出生后第60天导致雌性大鼠肾脏出现各种变化。
