Institute of Islamic Civilization, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor Darul Ehsan, Malaysia.
Department of Nursing, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, Kuala Lumpur, Malaysia.
Int J Mol Sci. 2023 Jul 21;24(14):11763. doi: 10.3390/ijms241411763.
Stem cells derived from human exfoliated deciduous teeth (SHED) have emerged as an alternative stem cell source for cell therapy and regenerative medicine because they are readily available, pose fewer ethical concerns, and have low immunogenicity and tumourigenicity. SHED offer a number of advantages over other dental stem cells, including a high proliferation rate with the potential to differentiate into multiple developmental lineages. The therapeutic effects of SHED are mediated by multiple mechanisms, including immunomodulation, angiogenesis, neurogenesis, osteogenesis, and adipogenesis. In recent years, there is ample evidence that the mechanism of action of SHED is mainly due to its paracrine action, releasing a wide range of soluble factors such as cytokines, chemokines, and trophic factors (also known as 'secretome') into the local tissue microenvironment to promote tissue survival and recovery. This review provides an overview of the secretome derived from SHED and highlights the bioactive molecules involved in tissue regeneration and their potential applications in regenerative medicine.
人脱落乳牙来源的干细胞（SHED）已成为细胞治疗和再生医学的另一种干细胞来源，因为它们易于获得，引发的伦理问题较少，免疫原性和致瘤性较低。SHED 相较于其他牙源性干细胞具有许多优势，包括高增殖率和分化为多种发育谱系的潜力。SHED 的治疗效果通过多种机制介导，包括免疫调节、血管生成、神经生成、成骨和脂肪生成。近年来，有充分的证据表明，SHED 的作用机制主要归因于其旁分泌作用，将广泛的可溶性因子（如细胞因子、趋化因子和营养因子，也称为“分泌组”）释放到局部组织微环境中，以促进组织存活和恢复。本综述概述了 SHED 分泌组，并强调了参与组织再生的生物活性分子及其在再生医学中的潜在应用。
