Shu Chang, Lim Maria, Fang Adam
Post-Baccalaureate Premed Program, Goucher College, Baltimore, MD 21204, USA.
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Life (Basel). 2023 Jun 30;13(7):1485. doi: 10.3390/life13071485.
Soft tissue tumors (STTs) include a range of benign and malignant tumors originating from soft tissues. Transarterial and percutaneous therapies are image-guided and minimally invasive approaches for managing primary and metastatic STTs. The objective of this review is to discuss transarterial and percutaneous therapies by examining the current literature, including indications, patient selection, safety, and effectiveness. Transarterial therapies (e.g., transarterial bland embolization and transarterial chemoembolization) involve the delivery of either embolic or chemotherapeutic particles using a catheter into arteries feeding the tumor, resulting in localized tumor destruction. Percutaneous therapies (e.g., radiofrequency ablation, cryoablation, irreversible electroporation, laser ablation, and magnetic resonance-guided high-intensity focused ultrasound) involve the delivery of either hot or cold temperatures, electrical current, laser, or ultrasound to specifically target tumor cells. Both therapies have been shown to be safe and effective for reducing morbidity and local control of STTs, specifically in patients who are surgically inoperable or who are unresponsive to conventional therapies. Accurate diagnosis, staging, and histological subtype identification are crucial for treatment selection. A multidisciplinary approach, a thorough understanding of tissue anatomy and surrounding structures, as well as individualized strategies based on assessment are essential for optimal patient care.
软组织肿瘤（STTs）包括一系列起源于软组织的良性和恶性肿瘤。经动脉和经皮治疗是用于处理原发性和转移性STTs的影像引导下的微创方法。本综述的目的是通过研究当前文献，包括适应症、患者选择、安全性和有效性，来讨论经动脉和经皮治疗。经动脉治疗（例如，经动脉单纯栓塞和经动脉化疗栓塞）涉及使用导管将栓塞剂或化疗颗粒输送到为肿瘤供血的动脉中，从而导致局部肿瘤破坏。经皮治疗（例如，射频消融、冷冻消融、不可逆电穿孔、激光消融和磁共振引导下的高强度聚焦超声）涉及输送热或冷温度、电流、激光或超声以特异性地靶向肿瘤细胞。两种治疗方法均已被证明对于降低STTs的发病率和局部控制是安全有效的，特别是对于那些手术无法切除或对传统治疗无反应的患者。准确的诊断、分期和组织学亚型识别对于治疗选择至关重要。多学科方法、对组织解剖结构和周围结构的透彻理解以及基于评估的个体化策略对于优化患者护理至关重要。
