Oboňová Bianka, Habala Ladislav, Litecká Miroslava, Herich Peter, Bilková Andrea, Bilka František, Horváth Branislav
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, 832 32 Bratislava, Slovakia.
Department of Materials Chemistry, Institute of Inorganic Chemistry of the CAS, Husinec-Řež č.p. 1001, 250 68 Řež, Czech Republic.
Life (Basel). 2023 Jul 6;13(7):1516. doi: 10.3390/life13071516.
A series of Schiff base ligands obtained by the condensation of -cyclohexane-1,2-diamine and fluorinated benzaldehydes were prepared, followed by their reduction with NaBH. The reduced ligands were employed in the synthesis of zinc complexes of the general formula [ZnCl(L)]. The structures of both the original and the reduced Schiff bases, as well as of the zinc complexes, were characterized by single-crystal X-ray analysis, along with NMR and IR spectroscopy. The antimicrobial activities of the reduced Schiff bases and their zinc complexes were evaluated in vitro against , , and . The compounds containing the 4-(trifluoromethylphenyl) moiety showed marked antibacterial activity. Interestingly, the antimicrobial effect of the zinc complex with this moiety was significantly higher than that of the corresponding free reduced ligand, comparable with ciprofloxacin used as standard. Thus, a synergic effect upon the complexation with zinc can be inferred.
通过1,2 - 环己二胺与氟化苯甲醛缩合制备了一系列席夫碱配体，随后用硼氢化钠对其进行还原。还原后的配体用于合成通式为[ZnCl(L)]的锌配合物。通过单晶X射线分析以及核磁共振和红外光谱对原始席夫碱、还原席夫碱以及锌配合物的结构进行了表征。对还原席夫碱及其锌配合物的抗菌活性进行了体外评估，针对的菌株有[此处原文缺失具体菌株名称]、[此处原文缺失具体菌株名称]和[此处原文缺失具体菌株名称]。含有4 - （三氟甲基苯基）部分的化合物表现出显著的抗菌活性。有趣的是，含有该部分的锌配合物的抗菌效果明显高于相应的游离还原配体，与用作标准的环丙沙星相当。因此，可以推断出与锌络合时有协同效应。
