Gherasie Flavius-Alexandru, Achim Alexandru
Department of Cardiology, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania.
Department of Cardiology, Medizinische Universitätsklinik, Kantonsspital Baselland, Rheinstrasse 26, 4410 Liestal, Switzerland.
Life (Basel). 2023 Jul 21;13(7):1605. doi: 10.3390/life13071605.
Due to technological advancements during the past 20 years, transcatheter aortic valve replacements (TAVRs) have significantly improved the treatment of symptomatic and severe aortic stenosis, significantly improving patient outcomes. The continuous evolution of transcatheter valve models, refined imaging planning for enhanced accuracy, and the growing expertise of technicians have collectively contributed to increased safety and procedural success over time. These notable advancements have expanded the scope of TAVR to include patients with lower risk profiles as it has consistently demonstrated more favorable outcomes than surgical aortic valve replacement (SAVR). As the field progresses, coronary angiography is anticipated to become increasingly prevalent among patients who have previously undergone TAVR, particularly in younger cohorts. It is worth noting that aortic stenosis is often associated with coronary artery disease. While the task of re-accessing coronary artery access following TAVR is challenging, it is generally feasible. In the context of valve-in-valve procedures, several crucial factors must be carefully considered to optimize coronary re-access. To obtain successful coronary re-access, it is essential to align the prosthesis with the native coronary ostia. As part of preventive measures, strategies have been developed to safeguard against coronary obstruction during TAVR. One such approach involves placing wires and non-deployed coronary balloons or scaffolds inside an at-risk coronary artery, a procedure known as chimney stenting. Additionally, the bioprosthetic or native aortic scallops intentional laceration to prevent iatrogenic coronary artery obstruction (BASILICA) procedure offers an effective and safer alternative to prevent coronary artery obstructions. The key objective of our study was to evaluate the techniques and procedures employed to achieve commissural alignment in TAVR, as well as to assess the efficacy and measure the impact on coronary re-access in valve-in-valve procedures.
由于过去20年的技术进步,经导管主动脉瓣置换术(TAVR)显著改善了有症状的重度主动脉瓣狭窄的治疗,显著改善了患者预后。随着时间的推移,经导管瓣膜模型的不断演变、为提高准确性而优化的成像规划以及技术人员专业知识的不断增长,共同提高了安全性并提升了手术成功率。这些显著进展扩大了TAVR的适用范围,将风险较低的患者纳入其中,因为它一直显示出比外科主动脉瓣置换术(SAVR)更有利的结果。随着该领域的发展,冠状动脉造影预计在先前接受过TAVR的患者中会越来越普遍,尤其是在年轻人群体中。值得注意的是,主动脉瓣狭窄常与冠状动脉疾病相关。虽然TAVR后重新进入冠状动脉通路具有挑战性,但总体上是可行的。在瓣中瓣手术的背景下,必须仔细考虑几个关键因素以优化冠状动脉重新进入。为了成功实现冠状动脉重新进入,使人工瓣膜与天然冠状动脉口对齐至关重要。作为预防措施的一部分,已经制定了在TAVR期间防止冠状动脉阻塞的策略。一种方法是将导丝和未展开的冠状动脉球囊或支架放置在有风险的冠状动脉内,这一过程称为烟囱支架置入术。此外,生物人工瓣膜或天然主动脉叶有意撕裂以预防医源性冠状动脉阻塞(BASILICA)手术提供了一种有效且更安全的预防冠状动脉阻塞的替代方法。我们研究的主要目的是评估在TAVR中实现瓣叶对齐所采用的技术和程序,以及评估在瓣中瓣手术中冠状动脉重新进入的疗效并衡量其影响。