Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea.
Medicina (Kaunas). 2023 Jul 24;59(7):1353. doi: 10.3390/medicina59071353.
: The fruit of (Turcz.) Baill. is widely used medicinally to treat coughs, asthma, exhaustion, eczema, and pruritus in Northeast Asian countries, including Korea, China, and Japan. This study was designed to investigate the effects of on dermatitis in mice with calcipotriol (MC-903)-induced atopic dermatitis (AD), and its effects on skin barrier dysfunction was also investigated. : The inhibitory effects of an ethanolic extract of (EESC) on skin lesions, water content, water-holding capacity (WHC), histopathological abnormalities, and inflammatory cytokine and chemokine levels were evaluated in mice with AD induced by MC903. : Topical EESC ameliorated skin lesions, reduced skin water content, and increased MC903-induced WHC. EESC also prevented MC-903-induced histopathological abnormalities such as epidermal disruption, hyperkeratosis, spongiotic changes, and immune cell infiltration in inflamed tissue. Moreover, topical EESC reduced MC-903-induced levels of pro-inflammatory cytokines and chemokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-4, IL-6, IL-8, monocyte chemotactic protein (MCP)-1, and thymic stromal lymphopoietin (TSLP). Furthermore, unlike dexamethasone, EESC did not reduce the spleen/body weight ratio. : These results suggest that can be used as an alternative to external corticosteroids and that its anti-inflammatory and skin barrier dysfunction-restoring effects are related to the downregulation of pro-inflammatory cytokines and chemokines, such as TNF-α, IL-4, IL-6, IL-8, and TSLP.
: （Turcz.）Baill. 的果实广泛应用于治疗咳嗽、哮喘、疲劳、湿疹和瘙痒等疾病，在包括韩国、中国和日本在内的东北亚国家被广泛应用。本研究旨在探讨（Turcz.）Baill. 对钙泊三醇（MC-903）诱导的特应性皮炎（AD）小鼠皮炎的影响，及其对皮肤屏障功能障碍的影响。 : 采用 MC903 诱导 AD 小鼠模型，评价（Turcz.）Baill. 乙醇提取物（EESC）对皮肤损伤、水分含量、持水能力（WHC）、组织病理学异常以及炎症细胞因子和趋化因子水平的抑制作用。 : EESC 可改善皮肤损伤，减少皮肤水分含量，增加 MC903 诱导的 WHC。EESC 还可预防 MC-903 诱导的组织病理学异常，如表皮破坏、角化过度、海绵状改变和炎症组织中免疫细胞浸润。此外，EESC 还可降低 MC-903 诱导的促炎细胞因子和趋化因子水平，如肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、IL-4、IL-6、IL-8、单核细胞趋化蛋白（MCP）-1 和胸腺基质淋巴细胞生成素（TSLP）。此外，与地塞米松不同，EESC 不会降低脾/体重比。 : 这些结果表明，（Turcz.）Baill. 可作为外用皮质类固醇的替代品，其抗炎和恢复皮肤屏障功能障碍的作用与下调 TNF-α、IL-4、IL-6、IL-8 和 TSLP 等促炎细胞因子和趋化因子有关。
