Chakraborty Sudip, Katsifis Georgio, Roohani Iman, Boyer Cyrille, McKenzie David, Willcox Mark D P, Chen Renxun, Kumar Naresh
School of Chemistry, UNSW Sydney, Sydney, NSW 2052, Australia.
School of Physics, University of Sydney, Sydney, NSW 2006, Australia.
Materials (Basel). 2023 Jul 17;16(14):5045. doi: 10.3390/ma16145045.
Orthopedic-device-related infections are notorious for causing physical and psychological trauma to patients suffering from them. Traditional methods of treating these infections have relied heavily on antibiotics and are becoming ineffectual due to the rise of antibiotic-resistant bacteria. Mimics of antimicrobial peptides have emerged as exciting alternatives due to their favorable antibacterial properties and lack of propensity for generating resistant bacteria. In this study, the efficacy of an antibacterial polymer as a coating material for hydroxyapatite and glass surfaces, two materials with wide ranging application in orthopedics and the biomedical sciences, is demonstrated. Both physical and covalent modes of attachment of the polymer to these materials were explored. Polymer attachment to the material surfaces was confirmed via X-ray photoelectron spectroscopy and contact angle measurements. The modified surfaces exhibited significant antibacterial activity against the Gram-negative bacterium , and the activity was retained for a prolonged period on the surfaces of the covalently modified materials.
与骨科器械相关的感染因给受其影响的患者带来身体和心理创伤而声名狼藉。治疗这些感染的传统方法严重依赖抗生素，而由于抗生素耐药菌的增加，这些方法正变得无效。抗菌肽模拟物因其良好的抗菌特性以及不易产生耐药菌的倾向，已成为令人兴奋的替代物。在本研究中，展示了一种抗菌聚合物作为羟基磷灰石和玻璃表面涂层材料的功效，这两种材料在骨科和生物医学科学中有广泛应用。探索了聚合物与这些材料的物理和共价附着方式。通过X射线光电子能谱和接触角测量证实了聚合物附着在材料表面。改性表面对革兰氏阴性菌表现出显著的抗菌活性，并且在共价改性材料的表面上这种活性能长时间保持。
