Center for Developmental Biology, School of Life Sciences, Anhui Agricultural University, Hefei 230036, Anhui, China.
Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian, China.
Molecules. 2023 Jul 9;28(14):5300. doi: 10.3390/molecules28145300.
Aspirin, also known as acetylsalicylic acid, is widely consumed as a pain reliever and an anti-inflammatory as well as anti-platelet agent. Recently, our studies using the animal model of demonstrated that the dietary supplementation of aspirin renovates age-onset intestinal dysfunction and delays organismal aging. Nevertheless, it remains probable that aspirin plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed that the replications of several types of viruses were drastically antagonized in macrophage-like S2 cells with the addition of aspirin. Further in vivo experimental approaches illustrate that adult flies consuming aspirin harbor higher resistances to viral infections with respect to flies without aspirin treatment. Mechanistically, aspirin positively contributes to the antiviral defense largely through mediating the STING (stimulator of interferon genes) but not the IMD (immune deficiency) signaling pathway. Collectively, our studies uncover a novel biological function of aspirin in modulating antiviral immunity and provide theoretical bases for exploring new antiviral treatments in clinical trials.
阿司匹林，又称乙酰水杨酸，广泛用作止痛和抗炎药以及抗血小板药物。最近，我们在动物模型中的研究表明，饮食补充阿司匹林可修复年龄相关性肠道功能障碍并延缓机体衰老。然而，阿司匹林可能在其他生物活性中发挥功能作用，例如抗病毒防御反应。有趣的是，我们观察到添加阿司匹林可显著抑制几种类型病毒在巨噬细胞样 S2 细胞中的复制。进一步的体内实验方法表明，摄入阿司匹林的成年果蝇相对于未接受阿司匹林处理的果蝇对病毒感染具有更高的抵抗力。从机制上讲，阿司匹林主要通过调节 STING（干扰素基因刺激物）而不是 IMD（免疫缺陷）信号通路来积极促进抗病毒防御。总的来说，我们的研究揭示了阿司匹林在调节抗病毒免疫中的新生物学功能，并为探索临床试验中的新抗病毒治疗方法提供了理论依据。
