Cai Qingshuang, Ji Shanming, Li Mengwan, Zheng Sen, Zhou Xiuhong, Guo Huimin, Deng Siyu, Zhu Junyan, Li Daxiang, Xie Zhongwen
State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Sciences and Technology, Anhui Agricultural University, Hefei, Anhui 230036, China.
School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China.
iScience. 2021 Feb 6;24(3):102150. doi: 10.1016/j.isci.2021.102150. eCollection 2021 Mar 19.
Black tea is the most widely consumed tea drink in the world and has consistently been reported to possess anti-aging benefits. However, whether theaflavins, one type of the characteristic phytochemicals in black tea extracts, are involved in regulating aging and lifespan in consumers remains largely unknown. In this study, we show that theaflavins play a beneficial role in preventing age-onset intestinal leakage and dysbiosis, thus delaying aging in . Mechanistically, theaflavins regulate the condensate assembly of Imd to negatively govern the overactivation of Imd signals in fruit fly intestines. In addition, theaflavins prevent DSS-induced colitis in mice, suggesting theaflavins play a role in modulating intestinal integrity. Overall, our study reveals a molecular mechanism by which theaflavins regulate gut homeostasis likely through controlling Imd coalescence.
红茶是世界上消费最广泛的茶饮料，一直有报道称其具有抗衰老功效。然而，红茶提取物中的一种特征性植物化学物质茶黄素是否参与调节消费者的衰老和寿命，在很大程度上仍不清楚。在本研究中，我们表明茶黄素在预防年龄相关的肠道渗漏和微生物群失调方面发挥有益作用，从而延缓衰老。从机制上讲，茶黄素调节果蝇肠道中Imd信号通路的过激活，从而负调控Imd信号通路的凝聚组装。此外，茶黄素可预防小鼠由葡聚糖硫酸钠（DSS）诱导的结肠炎，表明茶黄素在调节肠道完整性方面发挥作用。总体而言，我们的研究揭示了一种分子机制，即茶黄素可能通过控制Imd凝聚来调节肠道稳态。
