吲哚衍生物：揭示药物化学与合成有机化学的新前沿
Indole Derivatives: Unveiling New Frontiers in Medicinal and Synthetic Organic Chemistry.
作者信息
Saleem Faiza, Khan Khalid Mohammed
机构信息
Husein Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Pakistan Academy of Science, 3-Constitution Avenue, G-5/2, Islamabad 44000, Pakistan.
出版信息
Molecules. 2023 Jul 18;28(14):5477. doi: 10.3390/molecules28145477.
Abstract
In recent years, significant attention has been given to indoles, a diverse group of heterocyclic compounds widely found in nature that play a crucial role in various bioactive natural and synthetic substances [...].
摘要
近年来，吲哚受到了广泛关注，它是一类多样的杂环化合物，在自然界中广泛存在，在各种生物活性天然和合成物质中起着关键作用[...]。
相似文献
1
Indole Derivatives: Unveiling New Frontiers in Medicinal and Synthetic Organic Chemistry.吲哚衍生物：揭示药物化学与合成有机化学的新前沿
Molecules. 2023 Jul 18;28(14):5477. doi: 10.3390/molecules28145477.
2
Recent Advances on Direct Functionalization of Indoles in Aqueous Media.吲哚在水相介质中的直接功能化研究进展
Chem Rec. 2023 Mar;23(3):e202200289. doi: 10.1002/tcr.202200289. Epub 2023 Feb 1.
3
Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles.杂环化合物的连续流合成：吲哚的流动合成最新进展。
Molecules. 2020 Jul 16;25(14):3242. doi: 10.3390/molecules25143242.
4
Medicinal Perspective of Indole Derivatives: Recent Developments and Structure-Activity Relationship Studies.吲哚衍生物的医学视角：最新进展与构效关系研究
Curr Drug Targets. 2020;21(9):864-891. doi: 10.2174/1389450121666200310115327.
5
Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications.手性有机催化轴向手性吲哚衍生物的合成：策略与应用。
Acc Chem Res. 2022 Sep 20;55(18):2562-2580. doi: 10.1021/acs.accounts.2c00465. Epub 2022 Sep 2.
6
Recent Developments in the Synthesis and Antimicrobial Activity of Indole and its Derivatives.吲哚及其衍生物的合成与抗菌活性的最新进展
Curr Org Synth. 2019;16(1):17-37. doi: 10.2174/1570179415666181113144939.
7
Indole-N-Carboxylic Acids and Indole-N-Carboxamides in Organic Synthesis.吲哚-N-羧酸和吲哚-N-羧酰胺在有机合成中的应用。
Chem Asian J. 2020 Apr 1;15(7):973-985. doi: 10.1002/asia.201901806. Epub 2020 Mar 2.
8
Chiral Pd-Catalyzed Enantioselective Syntheses of Various N-C Axially Chiral Compounds and Their Synthetic Applications.手性 Pd 催化的各种 N-C 轴手性化合物的对映选择性合成及其合成应用。
Acc Chem Res. 2021 Feb 2;54(3):719-730. doi: 10.1021/acs.accounts.0c00767. Epub 2021 Jan 22.
9
Indole Derivatives as Anti-Tubercular Agents: An Overview on their Synthesis and Biological Activities.吲哚衍生物作为抗结核药物：合成与生物活性概述。
Curr Med Chem. 2021;28(22):4531-4568. doi: 10.2174/0929867327666200918144709.
10
Recent developments in green approaches for sustainable synthesis of indole-derived scaffolds.绿色方法在吲哚衍生支架可持续合成中的最新进展。
Mol Divers. 2022 Dec;26(6):3411-3445. doi: 10.1007/s11030-021-10376-3. Epub 2022 Jan 15.
引用本文的文献
1
Chiral pyrimidinyl-piperazine carboxamide derivatives as potent yeast α-glucosidase inhibitors.手性嘧啶基哌嗪甲酰胺衍生物作为有效的酵母α-葡萄糖苷酶抑制剂
Sci Rep. 2025 Jul 2;15(1):23241. doi: 10.1038/s41598-025-06104-8.
本文引用的文献
1
Novel Approach to the Construction of Fused Indolizine Scaffolds: Synthesis of Rosettacin and the Aromathecin Family of Compounds.新型融合吲哚里西啶骨架的构建方法：罗塞塔辛和芳香菌素类化合物的合成。
Molecules. 2023 May 12;28(10):4059. doi: 10.3390/molecules28104059.
2
Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents.基于靶点的抗癌吲哚衍生物用于开发抗神经胶质瘤药物。
Molecules. 2023 Mar 13;28(6):2587. doi: 10.3390/molecules28062587.
3
Indomethacin: Effect of Diffusionless Crystal Growth on Thermal Stability during Long-Term Storage.吲哚美辛：无扩散晶体生长对长期储存过程热稳定性的影响。
Molecules. 2023 Feb 6;28(4):1568. doi: 10.3390/molecules28041568.
4
Novel Indole-Containing Hybrids Derived from Millepachine: Synthesis, Biological Evaluation and Antitumor Mechanism Study.新型吲哚类米利钯宁衍生物的合成、生物评价及抗肿瘤作用机制研究。
Molecules. 2023 Feb 3;28(3):1481. doi: 10.3390/molecules28031481.
5
Approved Small-Molecule ATP-Competitive Kinases Drugs Containing Indole/Azaindole/Oxindole Scaffolds: R&D and Binding Patterns Profiling.含吲哚/氮茚/色满骨架的小分子 ATP 竞争型激酶类药物的研发及结合模式分析。
Molecules. 2023 Jan 17;28(3):943. doi: 10.3390/molecules28030943.
6
Indole Derivatives Bearing Imidazole, Benzothiazole-2-Thione or Benzoxazole-2-Thione Moieties-Synthesis, Structure and Evaluation of Their Cytoprotective, Antioxidant, Antibacterial and Fungicidal Activities.吲哚衍生物具有咪唑、苯并噻唑-2-硫酮或苯并恶唑-2-硫酮部分-它们的细胞保护、抗氧化、抗菌和抗真菌活性的合成、结构和评价。
Molecules. 2023 Jan 10;28(2):708. doi: 10.3390/molecules28020708.
7
Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold.螺噁嗪吲哚：一种多功能的生物活性杂环支架。
Molecules. 2023 Jan 7;28(2):618. doi: 10.3390/molecules28020618.
8
Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT and 5-HT Receptor Ligands.吲哚衍生物 D2AAK5、D2AAK6 和 D2AAK7 的合成、结构和行为研究作为血清素 5-HT 和 5-HT 受体配体。
Molecules. 2023 Jan 2;28(1):383. doi: 10.3390/molecules28010383.
9
Chemoenzymatic Synthesis of Indole-Containing Acyloin Derivatives.吲哚含酰基醇衍生物的酶促合成。
Molecules. 2023 Jan 1;28(1):354. doi: 10.3390/molecules28010354.
10
Synthesis and Antiproliferative Activity against Cancer Cells of Indole-Aryl-Amide Derivatives.吲哚-芳基酰胺衍生物的合成及对癌细胞的抗增殖活性。
Molecules. 2022 Dec 28;28(1):265. doi: 10.3390/molecules28010265.
Zotero 插件