Facultad de Fisioterapia y Enfermería, Universidad de Castilla-La Mancha, 45071 Toledo, Spain.
Hospital Universitario de Toledo, 45007 Toledo, Spain.
Nutrients. 2023 Jul 12;15(14):3114. doi: 10.3390/nu15143114.
Crohn's disease (CD) is a subtype of inflammatory bowel disease (IBD). CD is a health problem in Western countries such as the US and European nations and is an idiopathic disease; however, certain cases of CD have been associated with intestinal dysbiosis. A systematic review with a meta-analysis was carried out to determine the efficacy of a diet rich in fiber with or without cointervention to improve remission rates for CD. The literature in the PubMed, Scopus, Web of Science, and ClinicalTrials databases was reviewed. The quality of the studies was evaluated using the Johanna Briggs Institute (JBI) scale. This review was conducted in accordance with the structure outlined in the PRISMA statement. In addition, a meta-analysis was performed with a 95% confidence interval (CI) and a random effects model. Eleven studies were included, totaling 2389 patients with CD. Applying a diet rich in fiber with or without the administration of routine therapies improved CD remission rates. Data regarding CD activity, remission time, and adverse effects derived from fiber consumption were analyzed. Consumption of fiber in the diet could improve remission rates for CD patients who receive or do not receive other treatment to maintain remission.
克罗恩病（CD）是炎症性肠病（IBD）的一种亚型。CD 是西方国家（如美国和欧洲国家）的健康问题，是一种特发性疾病；然而，某些 CD 病例与肠道菌群失调有关。进行了一项系统评价和荟萃分析，以确定富含纤维的饮食是否联合或不联合其他干预措施来提高 CD 的缓解率。对 PubMed、Scopus、Web of Science 和 ClinicalTrials 数据库中的文献进行了回顾。使用 Johanna Briggs 研究所（JBI）量表评估研究的质量。本综述按照 PRISMA 声明中概述的结构进行。此外，还进行了荟萃分析，置信区间（CI）为 95%，采用随机效应模型。纳入了 11 项研究，共有 2389 例 CD 患者。应用富含纤维的饮食，无论是否联合常规治疗，均可提高 CD 的缓解率。分析了纤维摄入对 CD 活动、缓解时间和不良反应的数据。饮食中摄入纤维可以提高接受或不接受其他维持缓解治疗的 CD 患者的缓解率。
