B Food Science Co., Ltd., Chita 478-0046, Aichi, Japan.
Clinical Research Center, Chiba University Hospital, Chiba 260-8677, Chiba, Japan.
Nutrients. 2023 Jul 24;15(14):3276. doi: 10.3390/nu15143276.
Constipation is common in children and can significantly affect quality of life. Prebiotics are reportedly helpful for constipation in adults, but few studies have examined their use in young children. In this study, the effect of 1-kestose (kestose), which has excellent bifidobacterial growth properties, on constipation in kindergarten children ( = 11) was compared with that of maltose ( = 12) in a randomized, double-blind study. Three grams of kestose per day for 8 weeks did not affect stool properties, but significantly increased the number of defecations per week (Median; 3 → 4 times/week, = 0.017, effect size = 0.53). A significant decrease in , a trend toward increased bifidobacteria, and a trend toward decreased were observed after kestose ingestion, while concentrations of short-chain fatty acids in stools were unchanged.
便秘在儿童中很常见，会显著影响生活质量。有报道称，益生元对成人便秘有帮助，但很少有研究检查其在幼儿中的使用。在这项研究中，在一项随机、双盲研究中比较了具有优异双歧杆菌生长特性的 1-蔗果三糖（蔗果三糖）（ = 11）对幼儿园儿童（ = 12）便秘的影响与麦芽糖（ = 12）的影响。每天服用 3 克蔗果三糖 8 周不会影响粪便特性，但每周排便次数显著增加（中位数；3 → 4 次/周， = 0.017，效应大小 = 0.53）。摄入蔗果三糖后， 显著减少，双歧杆菌增加趋势， 减少趋势，而粪便中短链脂肪酸的浓度保持不变。
