Cordonin Colette, Gomard Yann, Monadjem Ara, Schoeman M Corrie, Le Minter Gildas, Lagadec Erwan, Gudo Eduardo S, Goodman Steven M, Dellagi Koussay, Mavingui Patrick, Tortosa Pablo
Unité Mixte de Recherche PIMIT "Processus Infectieux en Milieu Insulaire Tropical", Centre National de la Recherche Scientifique 9192, Institut National de la Santé Et de la Recherche Médicale 1187, Institut de Recherche pour le Développement 249, Université de La Réunion, Plateforme de Recherche CYROI, 97490 Sainte Clotilde, Réunion.
Department of Biological Sciences, University of Eswatini, Private Bag 4, Kwaluseni M202, Eswatini.
Pathogens. 2023 Jun 21;12(7):859. doi: 10.3390/pathogens12070859.
Madagascar is home to an extraordinary diversity of endemic mammals hosting several zoonotic pathogens. Although the African origin of Malagasy mammals has been addressed for a number of volant and terrestrial taxa, the origin of their hosted zoonotic pathogens is currently unknown. Using bats and infections as a model system, we tested whether Malagasy mammal hosts acquired these infections on the island following colonization events, or alternatively brought these bacteria from continental Africa. We first described the genetic diversity of pathogenic infecting bats from Mozambique and then tested through analyses of molecular variance (AMOVA) whether the genetic diversity of hosted by bats from Mozambique, Madagascar and Comoros is structured by geography or by their host phylogeny. This study reveals a wide diversity of lineages shed by bats from Mozambique. AMOVA strongly supports that the diversity of sequences obtained from bats sampled in Mozambique, Madagascar, and Comoros is structured according to bat phylogeny. Presented data show that a number of lineages detected in bat congeners from continental Africa and Madagascar are imbedded within monophyletic clades, strongly suggesting that bat colonists have indeed originally crossed the Mozambique Channel while infected with pathogenic .
马达加斯加是多种特有哺乳动物的家园，这些动物携带着多种人畜共患病原体。尽管马达加斯加哺乳动物的非洲起源已在一些会飞的和陆生的分类群中得到探讨，但其所携带的人畜共患病原体的起源目前尚不清楚。我们以蝙蝠及其感染情况作为一个模型系统，来测试马达加斯加的哺乳动物宿主是在岛屿殖民化事件之后在岛上感染这些病原体的，还是从非洲大陆带来这些细菌的。我们首先描述了感染莫桑比克蝙蝠的致病性[细菌名称]的遗传多样性，然后通过分子方差分析（AMOVA）来测试由莫桑比克、马达加斯加和科摩罗的蝙蝠所携带的[细菌名称]的遗传多样性是由地理因素还是由其宿主系统发育所构成。这项研究揭示了莫桑比克蝙蝠所携带的[细菌名称]谱系具有广泛的多样性。AMOVA有力地支持了从莫桑比克、马达加斯加和科摩罗采集的蝙蝠样本中获得的[细菌名称]序列的多样性是根据蝙蝠的系统发育构建的。所呈现的数据表明，在非洲大陆和马达加斯加的同属蝙蝠中检测到的许多[细菌名称]谱系都嵌入在单系类群中，这强烈表明蝙蝠殖民者在感染致病性[细菌名称]的情况下确实最初穿越了莫桑比克海峡。
