Santinelli-Pestana Diego V, Aikawa Elena, Singh Sasha A, Aikawa Masanori
Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Center for Excellence in Vascular Biology, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Pathogens. 2023 Jul 23;12(7):964. doi: 10.3390/pathogens12070964.
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is associated with multiple disease processes such as infections and chronic inflammatory diseases. The poly(ADP-ribose) polymerase (PARP)/ADP-ribosyltransferase (ART) family members promote mono- or poly-ADP-ribosylation. Although evidence has linked PARPs/ARTs and macrophages in the context of chronic inflammation, the underlying mechanisms remain incompletely understood. This review provides an overview of literature focusing on the roles of PARP1/ARTD1, PARP7/ARTD14, PARP9/ARTD9, and PARP14/ARTD8 in macrophages. PARPs/ARTs regulate changes in macrophages during chronic inflammatory processes not only via catalytic modifications but also via non-catalytic mechanisms. Untangling complex mechanisms, by which PARPs/ARTs modulate macrophage phenotype, and providing molecular bases for the development of new therapeutics require the development and implementation of innovative technologies.
蛋白质和核酸的异常二磷酸腺苷 - 核糖（ADP） - 核糖基化与多种疾病过程相关，如感染和慢性炎症性疾病。聚（ADP - 核糖）聚合酶（PARP）/ ADP - 核糖基转移酶（ART）家族成员促进单 - 或多 - ADP - 核糖基化。尽管有证据表明在慢性炎症的背景下PARP / ART与巨噬细胞有关，但其潜在机制仍未完全了解。本综述概述了聚焦于PARP1 / ARTD1、PARP7 / ARTD14、PARP9 / ARTD9和PARP14 / ARTD8在巨噬细胞中作用的文献。PARP / ART不仅通过催化修饰，还通过非催化机制调节慢性炎症过程中巨噬细胞的变化。理清PARP / ART调节巨噬细胞表型的复杂机制，并为开发新疗法提供分子基础，需要开发和应用创新技术。
