Zhou Qian, Li Tian, Fang Gang, Pang Yuzhou, Wang Xueni
Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, China.
School of Basic Medical Science, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, China.
Pharmaceuticals (Basel). 2023 Jul 3;16(7):952. doi: 10.3390/ph16070952.
Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death associated with an inflammatory response. Pyroptosis, which occurs in synovial and osteoblastic cells, can exacerbate the development of rheumatoid arthritis. The inhibition of pyroptosis of these cells can, therefore, clearly be used as a therapeutic strategy against rheumatoid arthritis. Here, we have summarized the current status of progress in the treatment of rheumatoid arthritis by targeting cellular pyroptosis. We have identified seven compounds, including a cyclic RNA, a microRNA, a peptide, and a cytokine (protein), that may influence the progression of rheumatoid arthritis by regulating the initiation of pyroptosis. All of these compounds have been shown to have anti-rheumatoid effects in vitro and/or in vivo and have the potential to be developed as anti-rheumatoid agents. These findings may help to accelerate the development of anti-rheumatoid arthritis drugs.
类风湿性关节炎是一种炎症性疾病，而细胞焦亡是一种与炎症反应相关的死亡形式。发生在滑膜细胞和成骨细胞中的细胞焦亡会加剧类风湿性关节炎的发展。因此，抑制这些细胞的细胞焦亡显然可作为治疗类风湿性关节炎的一种策略。在此，我们总结了通过靶向细胞焦亡治疗类风湿性关节炎的研究进展现状。我们确定了七种化合物，包括一种环状RNA、一种微小RNA、一种肽和一种细胞因子（蛋白质），它们可能通过调节细胞焦亡的启动来影响类风湿性关节炎的进展。所有这些化合物在体外和/或体内均已显示出抗类风湿作用，并且有潜力被开发为抗类风湿药物。这些发现可能有助于加速抗类风湿性关节炎药物的研发。
