Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Organogenesis. 2023 Dec 31;19(1):2177484. doi: 10.1080/15476278.2023.2177484.
Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of programmed cell death is dependent on inflammatory caspase activation, which cleaves gasdermin-D (GSDMD) to form membrane pores and initiates the release of pro-inflammatory cytokines. Pyroptosis plays an important role in achieving immune regulation and homeostasis within various organ systems. The role of GSDMD in pyroptosis has been extensively studied in recent years. In this review, we summarize the role of GSDMD in cellular and organ injury mediated by pyroptosis. We will also provide an outlook on GSDMD therapeutic targets in various organ systems.
Gasdermin-D (GSDMD) 属于 Gasdermin 家族 (GSDM)，是一种形成孔的效应蛋白，可促进炎症细胞死亡，也称为细胞焦亡。这种类型的程序性细胞死亡依赖于炎症半胱天冬酶的激活，其可切割 Gasdermin-D (GSDMD) 以形成膜孔，并启动促炎细胞因子的释放。细胞焦亡在各种器官系统中实现免疫调节和动态平衡方面发挥着重要作用。近年来，人们对 GSDMD 在细胞焦亡介导的细胞和器官损伤中的作用进行了广泛研究。在这篇综述中，我们总结了 GSDMD 在细胞焦亡介导的细胞和器官损伤中的作用。我们还将展望 GSDMD 在各个器官系统中的治疗靶点。
